Skip to main content

Weight regain after gastric bypass

Aug. 15, 2014, 8:00 AM

(iStock)

Bariatric surgery, including gastric bypass, is the most effective weight loss approach for obesity. Naji Abumrad, M.D., Robyn Tamboli, Ph.D., and colleagues evaluated whether early weight regain is detrimental to the metabolic improvements that occur after gastric bypass surgery.

The investigators assessed weight, insulin sensitivity and levels of the hormones ghrelin and leptin in patients before and for two years after Roux-en-Y gastric bypass surgery. They found that weight regain occurred in 33 percent of the subjects, but it was not associated with worsening of peripheral or hepatic insulin sensitivity. Subjects with weight regain had higher pre- and post-operative levels of ghrelin, which increases food intake, compared to those who maintained or lost weight after surgery.

The findings, published in the July issue of the journal Obesity, show that early weight regain after gastric bypass does not reverse improvements in insulin sensitivity. Also, higher pre-operative ghrelin levels might identify patients who are more susceptible to weight regain and might benefit from intensive follow-up treatment.

This research was supported by grants from the National Institutes of Health (DK070860, DK091748, TR000445, DK020593, DK059637, DK058404).

Send suggestions for articles to highlight in Aliquots and any other feedback about the column to aliquots@vanderbilt.edu

Recent Stories from VUMC News and Communications Publications

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

Vanderbilt Medicine

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Hope

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

Momentum

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

more