Skip to main content

Blocking neuroblastoma cell growth

Mar. 22, 2017, 8:00 AM

Neuroblastoma – a cancer that starts in nerve tissue outside of the brain – is the third most common cancer in children and accounts for about 15 percent of pediatric cancer-related deaths.

MYC proteins drive neuroblastoma tumorigenesis in part by promoting the expression of key glycolytic enzymes such as LDHA to induce aerobic glycolysis (a type of cellular metabolism).

Dai Chung, M.D., and colleagues tested the effects of FX11, a selective inhibitor of LDHA, in a series of neuroblastoma cell lines. They found that FX11 inhibited aerobic glycolysis and growth in neuroblastoma cell lines with single-copy and amplified MYC genes. FX11 caused cell cycle arrest and induction of programmed cell death in the neuroblastoma cell lines.

The findings, reported in the March issue of Surgery, demonstrate that LDHA is a potential target for the development of novel neuroblastoma treatments and suggest that LDHA antagonists should be further tested in preclinical neuroblastoma models.

This research was supported by the National Institutes of Health (grant DK061470), The American College of Surgeons Resident Research Scholarship and the Rally Foundation for Cancer Research.

Send suggestions for articles to highlight in Aliquots and any other feedback about the column to aliquots@vanderbilt.edu

Recent Stories from VUMC News and Communications Publications

Sharon Seibert is among the more than 5,000 patients who have received a stem cell transplant at Vanderbilt-Ingram Cancer Center, which has one of the best survival rates in the nation and is at the forefront of new cellular therapies.

Momentum

Sharon Seibert is among the more than 5,000 patients who have received a stem cell transplant at Vanderbilt-Ingram Cancer Center, which has one of the best survival rates in the nation and is at the forefront of new cellular therapies.

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Hope

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Vanderbilt Nurse

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

more