Skip to main content

RSV-HRV viral interference

May. 15, 2017, 12:00 PM

Viral interference – the influence of one virus on infection by another virus – is important in understanding respiratory viral circulation and the impact of vaccines.

Tina Hartert, M.D., MPH, visiting student Niek Achten, and colleagues, studied viral interference between respiratory syncytial virus (RSV) and human rhinovirus (HRV), the most common viruses associated with acute respiratory tract infections in infants.

The investigators evaluated cases of RSV and HRV in three populations of infants. They found that the risk of HRV infection was lower in RSV-infected infants in all groups. In a randomized population, infants who were administered RSV immunoprophylaxis to prevent RSV infection were more likely to have HRV infection.

The findings, reported in the Journal of Infectious Diseases, demonstrate a reduced risk of HRV when infected with RSV. The association was consistent across three distinct populations of infants spanning a decade of study, different geographical regions and varying disease severity.

The phenomenon of RSV-HRV interference may influence vaccine development and prevention strategies for viral respiratory tract infections in infants.

This research was supported by the National Institutes of Health (grants AI095227, AI077930), Abbott Laboratories, the Netherlands Organization for Health Research and Development and a Vanderbilt Clinical and Translational Science Award (NIH grant TR000445).

Send suggestions for articles to highlight in Aliquots and any other feedback about the column to aliquots@vanderbilt.edu

Recent Stories from VUMC News and Communications Publications

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

Vanderbilt Medicine

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Hope

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

Momentum

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

more