Skip to main content

A critical factor for wound healing

Jul. 16, 2019, 8:30 AM

by Anivarya Kumar

The p53 family of transcription factors (p63 and p73) plays critical roles in keratinocyte (skin cell) function.

Using mouse skin as a model system, J. Scott Beeler, Jennifer Pietenpol, PhD, and colleagues found that p73 is required for the timely healing of cutaneous wounds. In normal tissue, p73 expression increased in response to wounding, whereas p73 deficiency resulted in delayed wound healing, they reported in the journal PLOS ONE.

The delay in healing in p73-deficient mice was accompanied by increased levels of biomarkers of the DNA damage response in basal keratinocytes at the epidermal wound edge. They also found that p73 was expressed by epidermal and hair follicle stem cells, which are required for wound healing.

Further, they discovered that p73 isoforms expressed in the skin enhance p63-mediated expression of keratinocyte genes during cellular reprogramming from a mesenchymal to basal keratinocyte-like cell.

The study establishes a role for p73 in cutaneous wound healing through regulation of basal keratinocyte function.

This research was supported by the National Institutes of Health (grants CA105436, CA070856, CA098131, CA068485, GM007347).

Recent Stories from VUMC News and Communications Publications

Sharon Seibert is among the more than 5,000 patients who have received a stem cell transplant at Vanderbilt-Ingram Cancer Center, which has one of the best survival rates in the nation and is at the forefront of new cellular therapies.

Momentum

Sharon Seibert is among the more than 5,000 patients who have received a stem cell transplant at Vanderbilt-Ingram Cancer Center, which has one of the best survival rates in the nation and is at the forefront of new cellular therapies.

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Hope

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Vanderbilt Nurse

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

more