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Basic Sciences Archives

Blueprint for rebuilding the heart

May. 9, 2019—Young-Jae Nam and colleagues are discovering how to express specific factors in connective tissue cells to turn them into heart muscle cells.

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The dynamic basement

May. 9, 2019—Vanderbilt scientists led by Andrea Page-McCaw have discovered a new way to analyze repair of basement membranes — important structural and functional components of tissues.

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A new antibiotic’s mechanism of action

Apr. 25, 2019—Vanderbilt investigators have characterized how a new first-in-class antibacterial drug works, which will guide the development of additional compounds that overcome antibacterial resistance.

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Immune ‘pruning’ in schizophrenia

Apr. 25, 2019—Ariel Deutch and colleagues have discovered that overactive brain immune cells during adolescence may contribute to schizophrenia.

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The arrestin-GPCR connection

Apr. 11, 2019—Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.

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Keeping bone in its place

Apr. 11, 2019—Jonathan Schoenecker and colleagues have discovered a new mechanism for the formation of bone in soft tissues — a complication of severe injuries that causes pain and limits mobility.

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Cancer’s SOS

Mar. 28, 2019—Stephen Fesik and colleagues are advancing cancer drug discovery with the characterization of small molecules that modulate RAS, an important target for anti-cancer therapies.

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Unraveling endocytosis

Mar. 28, 2019—New discoveries by Jason MacGurn and colleagues further understanding of the complex machinery that cells use take up substances from outside the cell.

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New way to stimulate learning?

Mar. 14, 2019—Vagus nerve stimulation could be beneficial for treating Alzheimer’s disease and other forms of cognitive impairment, Vanderbilt research findings suggest.

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Correctly copying DNA

Mar. 14, 2019—A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

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Reprogramming cells for kidney repair

Mar. 14, 2019—Using gene transfer technologies to reprogram adult human kidney cells could lead to novel therapies for chronic kidney disease.

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Achilles’ heel for kidney cancer

Feb. 28, 2019—The discovery that kidney cells with mutations in a certain gene are sensitive to therapies called PI3K inhibitors opens new opportunities for applying precision medicine to cancer treatment.

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Recent Stories from VUMC News and Communications Publications

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

Vanderbilt Medicine

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Hope

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

Momentum

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

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