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Basic Sciences Archives

New way to stimulate learning?

Mar. 14, 2019—Vagus nerve stimulation could be beneficial for treating Alzheimer’s disease and other forms of cognitive impairment, Vanderbilt research findings suggest.

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Correctly copying DNA

Mar. 14, 2019—A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

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Reprogramming cells for kidney repair

Mar. 14, 2019—Using gene transfer technologies to reprogram adult human kidney cells could lead to novel therapies for chronic kidney disease.

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Achilles’ heel for kidney cancer

Feb. 28, 2019—The discovery that kidney cells with mutations in a certain gene are sensitive to therapies called PI3K inhibitors opens new opportunities for applying precision medicine to cancer treatment.

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Novel DNA repair mechanism preserves genome integrity: study

Feb. 28, 2019—Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.

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The yin and yang of cell signaling

Feb. 14, 2019—Larry Marnett and colleagues have explored the role of two enzymes in metabolizing molecules associated with cell proliferation, inflammatory processes and neurological diseases.

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Modulating stress circuits

Feb. 14, 2019—Danny Winder and colleagues demonstrate an interaction between two signaling pathways — and its impact on the activity of neurons that respond to stress.

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Adhesion protein optimizes border

Feb. 14, 2019—Matthew Tyska and colleagues have found that an adhesion protein plays a key role in building the intestinal brush border that is essential for absorbing nutrients.

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New target for chronic kidney disease

Jan. 31, 2019—Preventing the formation of secretory structures that promote scarring in the kidney could offer new therapeutic options for a disease that affects millions of people worldwide.

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Cell death pathway implicated in bone marrow failure

Jan. 31, 2019—Vanderbilt investigators have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure.

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Signals from the “conveyor belt”

Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

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DNA’s on/off switch

Jan. 17, 2019—DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

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Recent Stories from VUMC News and Communications Publications

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

Vanderbilt Medicine

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Hope

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

Momentum

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

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