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Cancer Research Archives

Study examines new breast cancer drug combination

Apr. 20, 2017—A study led by Vanderbilt-Ingram Cancer Center (VICC) investigators suggests a drug combination which includes a PDK1 protein blocker may be more effective for breast cancer that has become resistant to cyclin-dependent kinase (CDK4/6) targeted therapy.

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V Foundation grants bolster cancer initiatives

Nov. 17, 2016—Two Vanderbilt-Ingram Cancer Center (VICC) investigators have earned grant awards from The V Foundation for Cancer Research, continuing the foundation’s support for innovative cancer research initiatives at VICC.

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In search of new cancer targets

Sep. 9, 2016—Vanderbilt researchers developed a new algorithm to find clinically targetable gene rearrangements in cancers.

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New breast cancer driver

Aug. 26, 2016—Vanderbilt investigators have demonstrated that a certain protein complex drives tumor progression in aggressive breast cancers.

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Switching breast cancer off

Apr. 14, 2016—Signaling by a receptor that is overexpressed in aggressive forms of breast cancer has been linked to glutamine metabolism, suggesting new anti-cancer therapeutic targets.

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Overcoming lung cancer drug resistance

Feb. 10, 2016—Vanderbilt investigators have discovered a way to overcome the resistance of some lung cancers to certain targeted therapies, which could lead to more effective treatments for lung cancer patients.

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Gene profile predicts metastasis

Feb. 9, 2015—A specific gene expression profile represents a novel, biologically relevant “signature” for identifying colon cancers with high risk of metastatic recurrence, Vanderbilt researchers have found.

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Study tracks combination therapy to treat melanoma

Jan. 8, 2015—Melanoma is the most lethal form of skin cancer, with high mortality rates. While new drugs have been approved to treat the disease, patients nearly always develop resistance to the therapies and the cancer advances.

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Immune cell activity and melanoma

Nov. 6, 2014—The activity of a certain factor in immune cells is essential for an anti-tumor response, emphasizing the need to consider the effects of anti-cancer therapies on immune cells.

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Optical imaging in drug therapy screens

Oct. 1, 2014—A non-invasive imaging tool could test potential cancer therapies quickly to personalize therapy for patients.

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Limiting breast cancer metastasis

Aug. 28, 2014—Vanderbilt researchers have identified a new target for blocking breast cancer metastasis.

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New target for breast cancer therapy

Jul. 31, 2014—The protein MTBP is overexpressed in an aggressive type of breast cancer, and it regulates another protein implicated in many cancer types, suggesting that it may be a good target for new therapeutics.

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