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delirium Archives

Antipsychotics ineffective for treating ICU delirium: study

Oct. 22, 2018—Critically ill patients are not benefiting from antipsychotic medications that have been used to treat delirium in intensive care units (ICUs) for more than four decades, according to a study released today in the New England Journal of Medicine.

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New center formed to treat, study ICU delirium, dementia

Oct. 4, 2018—Millions of patients in intensive care units each year develop delirium during their hospitalization and often leave the hospital with cognitive deficits similar to those suffering from traumatic brain injury or mild Alzheimer’s disease.

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Sedative-associated delirium increases risk of dementia

Mar. 29, 2018—A Vanderbilt study of more than 1,000 intensive care unit patients around the country, nearly three-fourths of whom experienced delirium, showed that many drugs given to sedate patients in the ICU are actually increasing their chances of — and duration of — delirium instead of helping them recover.

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Study seeks to aid diagnosis, management of catatonia

Dec. 7, 2017—Catatonia, a syndrome of motor, emotional and behavioral abnormalities frequently characterized by muscular rigidity and a trance-like mental stupor and at times manifesting with great excitement or agitation, can occur during a critical illness and appear similar to delirium. But the management strategies are vastly different.

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Delirium, benzos and the pediatric ICU

Oct. 2, 2017—With other risk factors held equal, children who received a benzodiazepine sedative drug were nearly three times more likely to experience delirium – confused thought – the following day.

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Delirium in the ED

Mar. 20, 2017—Interventions for delirium in the emergency department setting are needed to preserve patients’ long-term function and cognition, Vanderbilt investigators have found.

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Delirium awareness promoted by Vanderbilt physicians

Mar. 15, 2017—Today is the inaugural World Delirium Day, created to raise delirium awareness and inspire positive action among health care providers.

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Risk factors for delirium

Sep. 13, 2016—High levels of blood markers for vascular endothelial dysfunction were associated with longer periods of confusion in ICU patients, Vanderbilt researchers have discovered.

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Delirium increases long-term disability

Mar. 17, 2014—Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge.

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Study finds cognitive deficits common after critical illness

Oct. 3, 2013—Patients treated in intensive care units across the globe enter their medical care with no evidence of cognitive impairment but often leave with deficits similar to those seen in patients with traumatic brain injury (TBI) or mild Alzheimer’s disease (AD) that persist for at least a year, according to a Vanderbilt University Medical Center study published today in the New England Journal of Medicine.

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A role for blood vessels in delirium?

Apr. 15, 2013—Dysfunction of the endothelial cells that line blood vessels may contribute to delirium and coma in critically ill patients – and could be a target for therapy.

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Grant to bolster care of ventilated ICU patients

Nov. 15, 2012—Vanderbilt University Medical Center investigators have received a $2.8 million grant from the National Heart, Lung, and Blood Institute (NHLBI) to continue studying ways to improve sedation management for intensive care unit patients who are on mechanical ventilators.

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