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Department of Veterans Affairs Archives

Spalluto, Lewis to lead VA lung screening initiative

Jan. 17, 2019—Lucy Spalluto, MD, assistant professor of Radiology and Radiological Sciences, and Jennifer Lewis, MD, MS, instructor in Medicine, have been selected to co-lead the Veterans Affairs — Partnership to increase Access to Lung Screening (VA-PALS) National Program Evaluation.

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Lean vs. obese adipose tissue cells

Dec. 13, 2018—A greater understanding of the mechanisms and cell types involved in returning adipose (fatty) tissue to the lean state may lead to more effective treatments for obesity.

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Lung cancer survival signal

Nov. 29, 2018—A receptor thought to be a cell growth inhibitor actually sends pro-survival signals in small cell lung cancer and is a candidate biomarker for poor prognosis.

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Vitamin C protects brain from seizures

Nov. 8, 2018—Brain ascorbate — vitamin C — is important for protecting the brain against seizures and cognitive decline in Alzheimer’s disease.

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Obesity negates beneficial drug effects

Nov. 8, 2018—A drug that improves levels of “good” cholesterol may not be beneficial for obese individuals, Vanderbilt researchers have discovered.

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Targeting diabetic kidney disease

Oct. 12, 2018—Pathways activated by the epidermal growth factor receptor may be attractive targets to treat diabetic kidney disease, according to new findings from Vanderbilt investigators.

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Fat tissue’s “iron sink”

Sep. 27, 2018—Alyssa Hasty and colleagues demonstrated that immune cells called macrophages act in fat tissue to store iron and prevent iron toxicity.

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Diabetes drug may prevent cancer

Sep. 14, 2018—The research suggests that metformin should be further studied clinically for the prevention of liver cancer.

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New histoplasmosis risk map

Sep. 14, 2018—The new mapping approach, called suitability score mapping, should improve public health assessments and interventions for geographic-specific infections.

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YAP after acute kidney injury

Aug. 16, 2018—Activation of the signaling protein YAP may be a target for treating acute kidney injury, which affects up to 20 percent of hospitalized patients.

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Team explores diabetes drug’s ability to treat RSV infection

Jul. 12, 2018—A drug used to treat diabetes may point to new therapies for respiratory syncytial virus (RSV) bronchiolitis — inflammation and obstruction of the lungs’ small airways. A multi-disciplinary team of Vanderbilt investigators has demonstrated that liraglutide reduces the inflammatory response to RSV infection in a mouse model of the disease.

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SMAD4 clue to colon cancer

Jul. 2, 2018—Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.

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