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DNA repair Archives

Pathways of radiosensitization

Apr. 11, 2019—Austin Kirschner and colleagues demonstrate how a hormone therapy for prostate cancer improves radiation’s tumor-killing power.

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Novel DNA repair mechanism preserves genome integrity: study

Feb. 28, 2019—Biochemistry investigators at Vanderbilt have discovered a new DNA repair mechanism that prevents gene mutations during DNA replication.

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Genetic balancing act

Aug. 2, 2018—New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.

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New player in DNA damage repair

Jul. 19, 2018—New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.

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DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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A new mode of DNA repair

Apr. 14, 2017—Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

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Mechanism of a DNA repair protein

Apr. 15, 2016—Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

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Copying chromosome caps

Jan. 8, 2016—Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.

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Study helps clarify components of DNA ‘copy machine’

Nov. 12, 2015—Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

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Study reveals how protein helps cells tolerate DNA damage

Jul. 16, 2015—Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage.

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Repair protein’s DNA recognition motif

May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

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Bypassing DNA damage

May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

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Recent Stories from VUMC News and Communications Publications

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Hope

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Vanderbilt Nurse

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

Vanderbilt Medicine

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

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