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DNA Archives

Correctly copying DNA

Mar. 14, 2019—A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.

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DNA’s on/off switch

Jan. 17, 2019—DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

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Vanderbilt experts discuss potential of universal genetic database to balance privacy, law enforcement concerns

Jan. 3, 2019—The pivotal role that long distance familial genetic searches played in the apprehension of the notorious Golden State Killer — and as a tool in dozens more cases since — has led experts from Vanderbilt University and Vanderbilt University Medical Center to make a provocative proposal about how investigative use of DNA should be regulated.

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New player in DNA damage repair

Jul. 19, 2018—New findings open opportunities to understand mechanisms of DNA repair for a toxic form of DNA damage.

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Study spots undiagnosed genetic diseases in EHR

Mar. 15, 2018—Patients diagnosed with heart failure, stroke, infertility and kidney failure could actually be suffering from rare and undiagnosed genetic diseases.

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Novel insights to antibiotic targets

Sep. 29, 2017—New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.

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Team identifies ‘switch’ involved in DNA replication  

Feb. 23, 2017—DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life. Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by a chemical “switch.”

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Saliva test for obesity risk

Jan. 24, 2017—“Epigenetic signatures” in DNA may present an opportunity for prevention of or early intervention in childhood obesity.

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Rheumatoid subtypes explored by PheWAS

Oct. 7, 2016—A computer-based method pioneered at Vanderbilt is being used to compare subtypes of rheumatoid arthritis.

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Mechanism of a DNA repair protein

Apr. 15, 2016—Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

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Faulty building blocks in DNA

Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

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Study helps clarify components of DNA ‘copy machine’

Nov. 12, 2015—Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.

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Recent Stories from VUMC News and Communications Publications

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

Vanderbilt University Adult Hospital with helipad

Vanderbilt University Adult Hospital with helipad

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