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drug resistance Archives

Key to prostate cancer resistance

Oct. 29, 2014—A combination of two types of therapy may be more effective in treating castration-resistant prostate cancer.

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How ABC transporters move molecules

Jun. 13, 2014—New views of how transporters move molecules across cell membranes are key to understanding how these proteins impact tumor cell drug resistance and inherited diseases such as cystic fibrosis.

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Dismantling staph’s drug resistance

Mar. 3, 2014—Targeting the enzyme FosB could make antibiotic-resistant staph bacteria sensitive to the antibiotic fosfomycin.

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Proton transfer powers multidrug resistance: study

Dec. 12, 2013—Vanderbilt University researchers and their Belgian colleagues have discovered the mechanism behind a multidrug transporter. Their findings, posted this week by Nature Chemical Biology, could lead to new treatments for multidrug resistant bacterial infections.

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VU study identifies DNA changes in drug-resistant cancer cells

Sep. 12, 2013—Vanderbilt investigators have combined next-generation sequencing technologies and bioinformatics analyses to screen for genome-wide genetic mutations associated with drug resistance in a series of lung cancer cell lines.

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Overcoming resistance in ovarian cancer

Aug. 22, 2013—The nuclear receptor TR3 contributes to ovarian cancer cell death in response to platinum-based chemotherapy – and may be a good target for overcoming cell resistance to certain treatments.

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HER2 may impact lung cancer therapy

Sep. 21, 2012—A protein associated with aggressive breast cancers may also influence resistance of lung cancer to targeted therapies.

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Recent Stories from VUMC News and Communications Publications

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

Vanderbilt University Adult Hospital with helipad

Vanderbilt University Adult Hospital with helipad

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