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F Guengerich Archives

Altered metabolism and disease

Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.

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Faulty building blocks in DNA

Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.

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Rational design of novel antifungals

Oct. 7, 2015—Structural and molecular details of an anti-fungal target's interaction with inhibitors suggest ways to design better treatments for fungal infections.

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How the cell makes morphine

Aug. 25, 2015—Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine.

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Bypassing DNA damage

May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

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Carcinogenic chemicals cramp DNA

Nov. 21, 2012—Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.

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An orphan enzyme’s purpose

Oct. 4, 2012—“Orphan” enzyme may play role in cancer growth, new research suggests.

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DNA: From modification to mutation

Jun. 8, 2012—Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.

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Recent Stories from VUMC News and Communications Publications

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

Vanderbilt Medicine

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Hope

A diagnosis of cancer at any age is tragic, but during the adolescent and young adult years, it’s especially complicated.

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

Momentum

Karen Dyer Young cares for patients and members of the Dayani Center who have or are recovering from cancer or a stem cell transplant.

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