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G protein-coupled receptors Archives

The arrestin-GPCR connection

Apr. 11, 2019—Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.

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New view of dopamine heteromers

Jan. 23, 2015—Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.

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VU researchers report G protein advancement that could lead to more effective drugs

Dec. 2, 2013—Thanks in part to a computer program named “Rosetta,” Vanderbilt University researchers are closer to understanding how the ubiquitous G protein is activated – a discovery that could lead to the design of more specific and effective drugs.

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Seeing light receptor’s interactions

Jan. 18, 2013—Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development.

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Hamm’s research honored by Dutch pharmacology society

Oct. 25, 2012—Heidi Hamm, Ph.D., chair of the Department of Pharmacology, has won the 2012 Ariens Award from the Dutch Pharmacological Society.

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Nobel in Chemistry reveals VU ties that bind

Oct. 18, 2012—Several Vanderbilt researchers have collaborated with this year's Nobel Chemistry winners.

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Recent Stories from VUMC News and Communications Publications

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

Vanderbilt University Adult Hospital with helipad

Vanderbilt University Adult Hospital with helipad

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