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genetic variant Archives

Tailoring treatment for heart defect

Sep. 23, 2019—By defining the clinical and genetic factors that predict treatment response, Vanderbilt investigators aim to personalize therapy for a common heart complication in preterm infants.

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Cancer susceptibility genes

Aug. 26, 2019—Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.

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Shared genetics may shape treatment options for certain brain disorders

Jun. 14, 2018—Symptoms of schizophrenia and bipolar disorder, including psychosis, depression and manic behavior, have both shared and distinguishing genetic factors, an international consortium led by researchers from Vanderbilt University and Virginia Commonwealth University is reporting.

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New breast cancer targets

May. 4, 2018—A special genetic analysis has revealed candidate genes associated with increased risk of breast cancer.

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Calcium intake and colorectal cancer

Oct. 18, 2017—Calcium intake appears to protect against colorectal cancer in individuals with certain gene variants, Vanderbilt researchers have discovered.

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NSAIDs, genetics and miscarriage

Sep. 20, 2017—A certain genetic variant, in combination with the use of anti-inflammatory drugs like aspirin and ibuprofen during early pregnancy, may protect women from miscarriage.

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Culprits in genetic epilepsies

Oct. 11, 2016—Genetic variation in GABA-A receptors confers risk for inherited forms of epilepsy.

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New technique helps spot atrial fibrillation genetic variations

May. 8, 2014—A technique called whole-exome sequencing (WES) has been used for the first time at Vanderbilt University to identify new genetic variations associated with a common disease — a heart rhythm abnormality called atrial fibrillation (AF).

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Potential mechanism for myeloma drug’s variable toxicity

Apr. 30, 2014—A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.

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A pain in the … genes

Jan. 10, 2014—Vanderbilt researchers have discovered that variation in the gene encoding the potassium channel GIRK1 plays a role in modulating human pain perception.

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Gene database to aid disease research

Jun. 19, 2012—A new catalog of human genetic data may help researchers uncover the genetic roots of disease and enable the ultimate realization of personalized medicine.

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New clue to ADHD

May. 15, 2012—A rare genetic change adds support to the idea that altered dopamine signaling is a key risk factor for ADHD.

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Recent Stories from VUMC News and Communications Publications

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

Vanderbilt University Adult Hospital with helipad

Vanderbilt University Adult Hospital with helipad

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