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immune response Archives

Breast cancer-killing RIG

Dec. 13, 2018—A compound that activates a virus-sensing receptor has potent therapeutic effects in a mouse model of breast cancer.

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RNA processing and antiviral immunity

Dec. 13, 2018—John Karijolich and colleagues have discovered a link between cellular RNA processing and the innate cellular immune response to viral pathogens.

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Asthma’s androgen connection

Oct. 12, 2018—New findings may explain why the prevalence of asthma is higher in women and suggest that testosterone derivatives may be useful for treating more severe types of asthma.

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Stretch, inflammation and hypertension

Sep. 27, 2018—New research sheds light on how changes in blood vessel forces enhance immune cell activation and promote hypertension.

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Team explores diabetes drug’s ability to treat RSV infection

Jul. 12, 2018—A drug used to treat diabetes may point to new therapies for respiratory syncytial virus (RSV) bronchiolitis — inflammation and obstruction of the lungs’ small airways. A multi-disciplinary team of Vanderbilt investigators has demonstrated that liraglutide reduces the inflammatory response to RSV infection in a mouse model of the disease.

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Karijolich named 2018 Pew Biomedical Scholar

Jun. 14, 2018—John Karijolich, PhD, assistant professor of Pathology, Microbiology, and Immunology at Vanderbilt University Medical Center, has been named a Pew Biomedical Scholar by The Pew Charitable Trusts.

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Disease-fighting antibody production

Apr. 20, 2018—New research links nutrient-responsive cellular signaling to the antibody-mediated immune response.

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A switch for autoimmunity

Oct. 12, 2017—Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies.

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Researcher targets peanut allergies with Cohen Fund support

Oct. 12, 2017—Scott Smith, M.D., Ph.D., assistant professor of Medicine, has received a 2017 research award from the Stanley Cohen Innovation Fund to test a new therapeutic strategy for peanut allergies. Smith's research could fundamentally change allergy treatment.

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Excess dietary manganese increases risk of staph infection in heart

Sep. 21, 2017—Too much dietary manganese — an essential trace mineral found in leafy green vegetables, fruits and nuts — promotes infection of the heart by the bacterium Staphylococcus aureus (“staph”).

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Pancreatic cancer development

Aug. 31, 2017—Elevated levels of the factor G-CSF appear to promote the development of aggressive pancreatic cancer, suggesting a new therapeutic approach for this devastating disease.

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Genetics of lung cancer survival

Jun. 29, 2017—Vanderbilt investigators have conducted a first-of-its-kind genome-wide association study of lung cancer survival in African-Americans.

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