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insulin Archives

Discovery may point to better treatments for Type 1 diabetes

Aug. 22, 2019—Researchers have made a paradigm-shifting discovery that could lead to new treatments, better health and longer life for patients with Type 1 diabetes.

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New role for microtubules in diabetes

Jul. 29, 2019—Microtubules — part of the cell's cytoskeleton — regulate the secretion of insulin, suggesting that they may be a new target for treating diabetes.

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Building a pancreas

Jan. 17, 2019—Vanderbilt investigators are defining the genetic programs that control the development of pancreatic beta cells — studies that could inform new cellular or regenerative therapies for diabetes.

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Insulin accelerant

Oct. 11, 2018—It’s possible to increase the permeability of blood vessels and accelerate insulin action in muscle, Vanderbilt researchers have discovered.

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Study may point to new ways to reverse insulin resistance

Jan. 25, 2018—Researchers at Vanderbilt University have discovered how insulin crosses the capillary endothelium to exit blood vessels and stimulate skeletal muscle cells — a major finding that may lead to new ways to reverse insulin resistance, a hallmark of type 2 diabetes.

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Cellular calcium handling in diabetes

Sep. 28, 2017—Potassium channels in a cellular organelle regulate calcium flux and appear to play a critical role in pancreatic beta cell health.

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Making human beta cells reproduce

Dec. 8, 2016—A new method developed at Vanderbilt will speed the search for potential therapeutics for diabetes: compounds that stimulate the replication of insulin-producing beta cells.

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Microtubules act as cellular ‘rheostat’ to control insulin secretion

Dec. 3, 2015—Microtubules — cellular “highways” that deliver cargo to the cell membrane for secretion — have a surprising role in pancreatic beta cells. Instead of facilitating glucose-stimulated insulin secretion, they limit it, a team of Vanderbilt investigators reported recently in Developmental Cell.

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Fighting type 2 diabetes with FGF1

Nov. 18, 2015—The growth factor FGF1 induces the growth of new insulin-producing beta cells and may help treat type 2 diabetes.

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Diabetes trial targets body’s ability to produce insulin

Sep. 10, 2015—Kiersten Eaddy had long looked forward to her high school graduation day and joining her classmates to celebrate the accomplishment.

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New therapeutic target for diabetes

Aug. 20, 2015—The factor FoxM1 increases the proliferation and function of insulin-producing beta cells, making it an attractive therapeutic target for diabetes.

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Boosting beta cells in diabetes

Apr. 20, 2015—New findings suggest that it might be possible to treat diabetes by regenerating insulin-producing beta cells in the pancreas.

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Recent Stories from VUMC News and Communications Publications

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

Vanderbilt University Adult Hospital with helipad

Vanderbilt University Adult Hospital with helipad

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