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NCI Archives

Immunotherapies linked to specific heart complications

Nov. 15, 2018—In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have shown that heart and vessel complications include myocarditis, pericarditis, vasculitis and arrhythmias, and that they occur early in the course of treatment.

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Team’s findings show glutamine metabolism affects T cell signaling

Nov. 1, 2018—The cellular nutrient glutamine launches a metabolic signaling pathway that promotes the function of some immune system T cells and suppresses others, Vanderbilt researchers have discovered.

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Clues to bone metastases

Oct. 26, 2018—Vanderbilt researchers are developing new approaches to study the mechanisms underlying why breast cancer cells home to bone and lie dormant, evading treatment.

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Studying cellular deliveries

Oct. 25, 2018—Vanderbilt researchers have characterized the functional transfer of long RNAs between colorectal cancer cells — a form of cell-cell communication that may contribute to cancer aggressiveness.

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Grant enhances study of new chemotherapy targets

Oct. 18, 2018—Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.

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Diabetes drug may prevent cancer

Sep. 14, 2018—The research suggests that metformin should be further studied clinically for the prevention of liver cancer.

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New histoplasmosis risk map

Sep. 14, 2018—The new mapping approach, called suitability score mapping, should improve public health assessments and interventions for geographic-specific infections.

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Unleashing TIGER on small RNAs

Sep. 5, 2018—Vanderbilt investigators have developed a new analytical tool to identify, quantify and analyze small RNAs.

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Energetic gene switch

Aug. 30, 2018—New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.

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A new target for lung cancer

Aug. 16, 2018—Vanderbilt researchers have identified a new vulnerability in lung cancer — the transporter protein xCT — that may a therapeutic target for the disease.

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Genetic balancing act

Aug. 2, 2018—New findings about proteins involved in DNA repair are important for understanding why some cancers are more or less resistant to certain therapies.

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Vanderbilt study links gene expression, disease association data

Jul. 26, 2018—An international team of researchers has integrated gene expression and disease association data to better understand the biological mechanisms of complex human diseases.

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