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NCI Archives

Signals from the “conveyor belt”

Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

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Building a pancreas

Jan. 17, 2019—Vanderbilt investigators are defining the genetic programs that control the development of pancreatic beta cells — studies that could inform new cellular or regenerative therapies for diabetes.

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Bile acids mediate metabolic benefits of weight-loss surgery

Jan. 10, 2019—A team of Vanderbilt investigators has pinpointed the role of bile acids and a specific signaling pathway in the positive metabolic effects of weight-loss surgery.

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Breast cancer-killing RIG

Dec. 13, 2018—A compound that activates a virus-sensing receptor has potent therapeutic effects in a mouse model of breast cancer.

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Analyzing single-cell landscapes

Nov. 29, 2018—Vanderbilt researchers have developed a new tool for quantifying data from single-cell studies.

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Green tea and diabetes

Nov. 29, 2018—In a large population study of Chinese adults, Vanderbilt researchers found that green tea drinking increased risk of type 2 diabetes.

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Immunotherapies linked to specific heart complications

Nov. 15, 2018—In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have shown that heart and vessel complications include myocarditis, pericarditis, vasculitis and arrhythmias, and that they occur early in the course of treatment.

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Team’s findings show glutamine metabolism affects T cell signaling

Nov. 1, 2018—The cellular nutrient glutamine launches a metabolic signaling pathway that promotes the function of some immune system T cells and suppresses others, Vanderbilt researchers have discovered.

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Clues to bone metastases

Oct. 26, 2018—Vanderbilt researchers are developing new approaches to study the mechanisms underlying why breast cancer cells home to bone and lie dormant, evading treatment.

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Studying cellular deliveries

Oct. 25, 2018—Vanderbilt researchers have characterized the functional transfer of long RNAs between colorectal cancer cells — a form of cell-cell communication that may contribute to cancer aggressiveness.

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Grant enhances study of new chemotherapy targets

Oct. 18, 2018—Vanderbilt chemists have been awarded $7.2 million over the next five years from the National Cancer Institute to lead an initiative to better understand how a combination chemotherapy for breast cancer targets DNA.

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Diabetes drug may prevent cancer

Sep. 14, 2018—The research suggests that metformin should be further studied clinically for the prevention of liver cancer.

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