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NIDDK Archives

SMAD4 clue to colon cancer

Jul. 2, 2018—Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.

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Mother knows best

Jul. 2, 2018—The first demonstration of bacterial DNA in mammalian fetal intestinal tissue suggests that the mother’s microbiome moves into the fetal intestine.

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Toxin floats on lipid rafts

Apr. 23, 2018—The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells.

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Disease-fighting antibody production

Apr. 20, 2018—New research links nutrient-responsive cellular signaling to the antibody-mediated immune response.

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Voluntary exercise and energy balance

Mar. 23, 2018—Non-exercise physical activity has a measurable energy expenditure, which goes down when animals engage in voluntary exercise, Vanderbilt researchers have discovered.

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Kidney disease imaging

Mar. 22, 2018—Making multiple measurements with MRI can provide comprehensive information about the molecular and cellular changes caused by kidney injury.

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Peek named to serve on NIDDK Advisory Council

Mar. 15, 2018—Richard Peek, MD, director of the Vanderbilt Digestive Disease Research Center (VDDRC) and chief of the Division of Gastroenterology, Hepatology and Nutrition, has been appointed to serve on the advisory council of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

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A new target for neuroblastoma

Feb. 14, 2018—Vanderbilt investigators have discovered that a sirtuin protein has oncogenic properties in neuroblastoma cells — and that blocking it reduces their growth and tumor-like characteristics.

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Cognition in rare hormonal disorder

Feb. 13, 2018—Vanderbilt investigators have conducted the first systematic evaluation of cognitive function in children with a rare genetic disorder.

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Cell skeleton and the brush border

Jan. 31, 2018—Vanderbilt researchers have discovered a role for microtubules — part of the cellular “skeleton” — in organizing the unique sidedness of the epithelial cells that line organs like the intestines.

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Lighting up iron levels

Jan. 11, 2018—A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease.

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Forming memories through CaMKII

Dec. 19, 2017—Vanderbilt researchers have identified an interaction between two proteins that play a role in learning and memory.

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