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NIGMS Archives

Signals from the “conveyor belt”

Jan. 17, 2019—Vanderbilt researchers propose that cellular signaling pathways are amplified by a “conveyor belt” mechanism that exchanges active and inactive enzymes.

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DNA’s on/off switch

Jan. 17, 2019—DNA-binding “switches” represent a fundamentally new method of communication between DNA-processing enzymes, Vanderbilt researchers propose.

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The exocyst dynamo

Dec. 13, 2018—New methods have revealed details of vesicle trafficking in cells and are applicable to any protein complexes, potentially revolutionizing our understanding of cell dynamics.

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Analyzing single-cell landscapes

Nov. 29, 2018—Vanderbilt researchers have developed a new tool for quantifying data from single-cell studies.

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Evading cell death

Nov. 8, 2018—Stress granules that form in response to cellular stress help cancer cells survive and develop resistance to treatment.

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Probing the genetics of fibroids

Oct. 1, 2018—A new study identified multiple genetic locations associated with the size and number of uterine fibroids — common non-cancerous uterine tumors.

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Fat tissue’s “iron sink”

Sep. 27, 2018—Alyssa Hasty and colleagues demonstrated that immune cells called macrophages act in fat tissue to store iron and prevent iron toxicity.

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Unleashing TIGER on small RNAs

Sep. 5, 2018—Vanderbilt investigators have developed a new analytical tool to identify, quantify and analyze small RNAs.

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A brain-builder called “Shh”

Aug. 30, 2018—New findings demonstrate a previously unappreciated role of Shh signaling activity in the proliferation of CGNPs — the presumed cell-of-origin for a subset of the malignant pediatric brain tumor medulloblastoma.

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Investigators find that bile acids reduce cocaine reward

Aug. 30, 2018—Bile acids — gut compounds that aid in the digestion of dietary fats — reduce the desire for cocaine, according to a new study by researchers at Vanderbilt and the University of Alabama at Birmingham.

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Predictive models for gene regulation

Aug. 16, 2018—Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.

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Repairs in the basement membrane

Aug. 2, 2018—Studies in fruit flies have shed light on how the basement membrane — a sheet-like scaffold that wraps around most animal tissues — is repaired after being damaged.

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