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NIH Archives

Vanderbilt study suggests way to prevent rare lung disease

Nov. 15, 2018—Research by Vanderbilt scientists suggests that it may be possible to prevent or even reverse pulmonary arterial hypertension, a rare, progressive disease characterized by narrowing of and high blood pressure in the small arteries of the lungs.

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Immunotherapies linked to specific heart complications

Nov. 15, 2018—In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have shown that heart and vessel complications include myocarditis, pericarditis, vasculitis and arrhythmias, and that they occur early in the course of treatment.

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Evading cell death

Nov. 8, 2018—Stress granules that form in response to cellular stress help cancer cells survive and develop resistance to treatment.

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Vitamin C protects brain from seizures

Nov. 8, 2018—Brain ascorbate — vitamin C — is important for protecting the brain against seizures and cognitive decline in Alzheimer’s disease.

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Novel methods to treat glaucoma

Nov. 8, 2018—Increasing a certain signaling molecule prevents the degeneration of retinal cells that are lost in glaucoma, suggesting a new way to treat this disease.

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Obesity negates beneficial drug effects

Nov. 8, 2018—A drug that improves levels of “good” cholesterol may not be beneficial for obese individuals, Vanderbilt researchers have discovered.

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Team’s findings show glutamine metabolism affects T cell signaling

Nov. 1, 2018—The cellular nutrient glutamine launches a metabolic signaling pathway that promotes the function of some immune system T cells and suppresses others, Vanderbilt researchers have discovered.

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Clues to bone metastases

Oct. 26, 2018—Vanderbilt researchers are developing new approaches to study the mechanisms underlying why breast cancer cells home to bone and lie dormant, evading treatment.

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Fetal membranes and microbial threats

Oct. 26, 2018—Understanding how cells communicate in the membranes surrounding the developing fetus could suggest new strategies for preventing infections, premature birth and adverse pregnancy outcomes.

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Probing the pathology of impaired cognition

Oct. 25, 2018—Detecting the neuropathology underlying cognitive impairment by lead to new targeted therapies.

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Studying cellular deliveries

Oct. 25, 2018—Vanderbilt researchers have characterized the functional transfer of long RNAs between colorectal cancer cells — a form of cell-cell communication that may contribute to cancer aggressiveness.

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Cellular stress defense

Oct. 12, 2018—The modular architecture of small heat-shock proteins contributes to the ability of these proteins to aid cells in responding to stress.

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