topoisomerase Archives
Completing DNA synthesis
Oct. 21, 2019—James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis.
Correctly copying DNA
Mar. 14, 2019—A precise understanding of how the enzyme topoisomerase II cuts DNA could lead to better anti-cancer therapies.
Novel insights to antibiotic targets
Sep. 29, 2017—New mechanistic details about the DNA-unwinding activity of antibacterial protein targets could lead to the design of better antibiotic medicines.
Slight chemical change may improve TB treatments: study
Feb. 11, 2016—One small chemical change to an existing antibacterial drug results in a compound that is more effective against its target enzyme in tuberculosis, Vanderbilt researchers have discovered.
Anticancer olive compounds
Jul. 27, 2015—Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet.
Antibiotics with anticancer potential
Feb. 25, 2015—A series of experimental antibiotics may be a good starting point for developing new anticancer drugs.
‘Detangler’ binds, bends and cuts DNA
Mar. 2, 2012—New details on the DNA-cutting activity of topoisomerase II, a target of anti-cancer drugs, could lead to better chemotherapeutic agents.
