Skip to main content

zebrafish Archives

Study merges big data and zebrafish biology to reveal mechanisms of human disease

Apr. 24, 2019—In a series of studies that volleyed between large databases and research in zebrafish, Vanderbilt investigators have discovered a link between vascular biology and eye disease.

Read more


A cataract-heart connection

Jan. 25, 2018—Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.

Read more


Fat hormone’s role in zebrafish

Mar. 8, 2016—The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

Read more


In a zebrafish’s eye

Jul. 29, 2015—Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts.

Read more


A “CRISPR” way to study disease

Jun. 11, 2015—Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases.

Read more


VU team explores new cholesterol processing pathway

Apr. 23, 2015—A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing.

Read more


Cancer signaling pathway blocker

Apr. 3, 2015—Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer.

Read more


Tiny model of diabetes

Feb. 20, 2015—Vanderbilt University researchers have created a zebrafish model of skeletal muscle insulin resistance that could help improve diabetes treatment.

Read more


Targeting tumor “supply lines”

Dec. 18, 2013—A metabolic enzyme plays a crucial role in vascular development and may be a good target for cancer therapies.

Read more


Fishing for new anti-cancer drugs

Sep. 18, 2013—Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.

Read more


Model for MADD mitochondrial disease

Jul. 11, 2013—A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches.

Read more


Setting traps to probe gene function

Oct. 18, 2012—A new method for creating genetic mutations that can be activated at certain times or in specific tissues will enable studies to probe gene function.

Read more


Recent Stories from VUMC News and Communications Publications

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Hope

The first few minutes of Charlie’s life were a blur, as a team of doctors and nurses at VUMC worked to resuscitate him and stabilize his heart rate. He was then transferred to the Neonatal Intensive Care Unit at Monroe Carell Jr. Children’s Hospital at Vanderbilt.

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Vanderbilt Nurse

Tucked away in a Vanderbilt conference room, 36 adults huddle over Lego pieces. Eleven teams have been assigned to assemble multicolored Legos using the written directions included in the packet. The result should be a Frankenstein figure.

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

Vanderbilt Medicine

Marissa Benchea has CF, and she is one of hundreds of thousands of adults not only surviving but thriving with a chronic childhood disease.

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

Vanderbilt Medicine

One hundred years ago, multiple “waves” of a deadly flu swept across the world.

more