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zebrafish Archives

A cataract-heart connection

Jan. 25, 2018—Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease.

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Fat hormone’s role in zebrafish

Mar. 8, 2016—The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

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In a zebrafish’s eye

Jul. 29, 2015—Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts.

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A “CRISPR” way to study disease

Jun. 11, 2015—Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases.

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VU team explores new cholesterol processing pathway

Apr. 23, 2015—A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing.

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Cancer signaling pathway blocker

Apr. 3, 2015—Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer.

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Tiny model of diabetes

Feb. 20, 2015—Vanderbilt University researchers have created a zebrafish model of skeletal muscle insulin resistance that could help improve diabetes treatment.

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Targeting tumor “supply lines”

Dec. 18, 2013—A metabolic enzyme plays a crucial role in vascular development and may be a good target for cancer therapies.

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Fishing for new anti-cancer drugs

Sep. 18, 2013—Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.

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Model for MADD mitochondrial disease

Jul. 11, 2013—A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches.

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Setting traps to probe gene function

Oct. 18, 2012—A new method for creating genetic mutations that can be activated at certain times or in specific tissues will enable studies to probe gene function.

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New tool hooks heart failure drugs

Apr. 6, 2012—A new screening tool – using glowing fish embryos – could identify therapeutics for myocardial hypertrophy and heart failure.

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