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Zhongming Zhao Archives

Drug signaling networks

Jul. 15, 2015—Vanderbilt investigators have developed a new algorithm to understand the networks of signaling molecules that control drug action.

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New data mining method reveals cancer-driving genes

Jan. 22, 2015—Prospecting for genes that might be implicated in cancer, a Vanderbilt University Medical Center research team has struck pay dirt.

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Protein “pockets” help ID cancer genes

Nov. 11, 2014—Vanderbilt investigators have used a computational biology approach to uncover new cancer drivers and biomarkers of anticancer drug response.

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Bradfords’ strong support bolsters melanoma research

Sep. 25, 2014—When something attacks you, you want to attack it back. That’s how Lillian “Tooty” Bradford views her late husband James “Jimmy” Bradford Jr.’s decision to make an initial gift to fund melanoma research at Vanderbilt-Ingram Cancer Center (VICC).

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VU study reveals shared pathways in psychiatric disorders

Sep. 18, 2014—Schizophrenia and bipolar disorder share common genetic underpinnings. Vanderbilt researchers combined high-resolution gene expression studies with gene association data to reveal signaling pathways linked to schizophrenia and bipolar disorder.

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Drug discovery clues in network map

Aug. 5, 2014—Vanderbilt investigators have constructed a network map that could guide the development of new targeted cancer therapies.

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Web tool speeds pulmonary hypertension discovery

Mar. 5, 2014—The pulmonary arterial hypertension knowledgebase (PAHKB), developed by Vanderbilt researchers, provides a useful tool for identifying PAH-related genes and signaling pathways relevant to pathogenesis.

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Molecular circuits in ovarian cancer

Nov. 13, 2013—Vanderbilt researchers have used bioinformatics analysis of gene expression data to describe molecular “circuits” that drive ovarian cancer.

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Gene interactions and cavities

Sep. 30, 2013—Vanderbilt researchers used existing genome-wide association study datasets to identify gene interactions that contribute to tooth decay.

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VU study identifies DNA changes in drug-resistant cancer cells

Sep. 12, 2013—Vanderbilt investigators have combined next-generation sequencing technologies and bioinformatics analyses to screen for genome-wide genetic mutations associated with drug resistance in a series of lung cancer cell lines.

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Network approach yields glioblastoma clues

Aug. 9, 2012—MicroRNA “regulatory networks” generated at Vanderbilt aid search for biomarkers and new drugs to treat glioblastoma, the most common and lethal primary brain tumor.

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Study finds mutation in melanoma sensitive to drug

Jul. 26, 2012—An uncommon mutation of the BRAF gene in melanoma patients has been found to respond to a specific drug therapy, providing a rationale for routine screening and therapy in melanoma patients who harbor the BRAF L597 mutation.

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