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Research

Role of immunity in kidney injury hints at a potential therapy: study

Dec. 5, 2023—Targeting the cytokine IL-22 could be a new therapeutic approach to prevent kidney injury caused by drugs or toxins, Vanderbilt researchers have discovered.

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Study links gene network and pancreatic beta cell defects to Type 2 diabetes

Dec. 4, 2023—A comprehensive study that integrates multiple analytic approaches has linked a regulatory gene network and functional defects in insulin-producing pancreatic beta cells to Type 2 diabetes.

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Nonprofits support quest to cure childhood epilepsy

Nov. 29, 2023—Monica Joanna Elnekaveh was doing everything she could to learn what was causing her 18-month-old daughter’s developmental issues. Her relentless quest to find answers eventually led her to Vanderbilt investigative neurologist Jing-Qiong (Katty) Kang, MD, PhD.

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Commensal gut bacterium protects from severe intestinal infection

Nov. 21, 2023— The commensal bacterium Turicibacter sanguinis could be used to protect against severe intestinal infections, Vanderbilt researchers discovered.

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VUMC scientists discover key step to kidney fibrosis

Nov. 21, 2023—Researchers at Vanderbilt University Medical Center for the first time have shown that activation of the epidermal growth factor receptor (EGFR) is essential for the development of kidney fibrosis, tissue scarring following injury that can lead to kidney failure.

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Tumor antigens key to improving cancer immunotherapy: study

Nov. 17, 2023—Vanderbilt researchers are working to better design immune therapies that attack tumors without also attacking healthy normal tissue in patients.

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Nasty microbe H. pylori has Achilles’ heel

Nov. 16, 2023—Vanderbilt researchers found that an H. pylori enzyme is essential for colonization of the stomach, suggesting it as a promising therapeutic target for H. pylori infection.

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Twelve at Vanderbilt are among world’s highly cited researchers

Nov. 15, 2023—Twelve current investigators at Vanderbilt University Medical Center and Vanderbilt University are on this year’s list of scientists whose papers have been cited the most frequently by other researchers.

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Novel C. diff structures are required for infection, offer new therapeutic targets

Nov. 15, 2023—Vanderbilt research discovers that iron storage “spheres” inside the bacterium C. diff — the leading cause of hospital-acquired infections — are important for infection in an animal model and could offer new targets for antibacterial drugs.

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Most can lower blood pressure by reducing salt, even those on BP drugs: study

Nov. 13, 2023—New research shows nearly everyone can lower their blood pressure, even people currently on blood pressure- reducing drugs, by lowering their sodium intake.

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After 40 years, genetics still surprises VUMC’s Nancy Cox

Nov. 10, 2023—As she looks back on her 40-plus year career, what surprises Nancy Cox, PhD, an internationally known geneticist at Vanderbilt University Medical Center, is how much progress has been made, and yet how much more there is to learn about the role genetic variation plays in human disease.

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Children’s antibodies highly potent against COVID-19: study

Nov. 6, 2023—Reporting Nov. 6 in Cell Reports Medicine, Ivelin Georgiev, PhD, and colleagues demonstrated that antibodies isolated from children’s blood samples displayed high levels of neutralization and potency against variants of the COVID-19 virus, SARS-CoV-2, even when the children had not previously been exposed to or vaccinated against those variants.

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