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Health and Medicine

Large study finds higher burden of acute brain dysfunction for COVID-19 ICU patients

Jan. 8, 2021—COVID-19 patients admitted to intensive care in the early months of the pandemic were subject to a significantly higher burden of delirium and coma than is typically found in patients with acute respiratory failure. Choice of sedative medications and curbs on family visitation played a role in increasing acute brain dysfunction for these patients.

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Vitamin D activation and cancer risk

Jan. 7, 2021—Vitamin D protection against colon cancer varies according to parathyroid hormone response, particularly among women.

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Building a cohort, the easy way

Jan. 7, 2021—An automated system using keyword searches can help identify candidates for clinical trials on adverse drug reactions.

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Functional seizures associated with stroke, psychiatric disorders in electronic health records study

Jan. 7, 2021—In a large-scale study of electronic health records, Vanderbilt University Medical Center investigators have determined the prevalence of functional seizures and characterized comorbidities associated with them.

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Genome editing technique “rescues” mice from accelerated aging disorder: study

Jan. 6, 2021—Researchers from the Broad Institute of Harvard and MIT, the National Institutes of Health (NIH) and Vanderbilt University Medical Center for the first time have used a novel genome-editing technique to “rescue” mice from progeria, a rare genetic disease that causes accelerated aging.

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VUMC, Case Western apply artificial intelligence to “customize” oral cancer treatment

Jan. 5, 2021—Researchers at Vanderbilt University Medical Center and Case Western Reserve University in Cleveland have been awarded a five-year, $3.3 million grant by the National Cancer Institute to apply artificial intelligence (AI) to help customize treatment for oral cancer patients.

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UT Southwestern’s Rosen up next in Discovery Lecture Series

Dec. 22, 2020—Michael Rosen, PhD, professor and chair of Biophysics at the University of Texas Southwestern Medical Center, will discuss mysterious cellular compartments known as “biomolecular condensates” during the next web-based Discovery Lecture.

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Pancreatlas provides access to complex images of the human pancreas

Dec. 22, 2020—Images of cells and tissues are a critical part of biomedical research as they show which molecules or proteins are present and where these molecules are located in the tissue. Using increasingly sophisticated microscopes and imaging approaches, scientists can now look at more than 40 different molecules at once, an approach known as multi-plex imaging, where in the past they could only look at three or four molecules at a time.

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Arthritis drug may treat immunotherapy-related heart complication

Dec. 22, 2020—by Tom Wilemon A drug typically prescribed for rheumatoid arthritis may also be effective in treating a rare but potentially deadly heart complication some cancer patients experience after taking immunotherapies, according to a study published in Cancer Discovery and co-led by investigators at Vanderbilt University Medical Center. The researchers demonstrated that the drug abatacept reduced...

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Study reveals new strategy for reducing tumor growth, metastasis

Dec. 17, 2020—A team of Vanderbilt investigators has discovered that blocking a certain signaling pathway boosts antitumor immunity and reduces tumor growth and metastasis in models of breast cancer and melanoma.

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COVID-associated delays for elective services studied

Dec. 17, 2020—This spring in the U.S., there were widespread delays in elective health care procedures and screenings. Hospitals, in observance of federal guidelines, were, for a time, conserving beds and protective equipment in preparation for a surge in COVID-19 admissions. And, perhaps on a more prolonged basis, patients in many areas of the country stayed away due to anxiety over catching COVID-19 from other patients or their health care team.

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Study reveals distinct genomic landscape for young adults with appendiceal cancer

Dec. 17, 2020—The first study to compare molecular landscapes of early-onset and late-onset appendiceal cancer has revealed distinct non-silent mutations in the tumors of younger patients, setting the stage for the development of potential therapeutic advances for this rare disease.

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