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adverse drug reactions Archives

Drug allergy labels in medical records power searches for gene-drug associations

Jun. 17, 2021—  by Paul Govern A meta-analysis published in 1998 in the Journal of the American Medical Association estimated that, leaving aside overdoses and cases of drug abuse, 2.2 million patients admitted to U.S. hospitals in 1994 (6.7% of the total) were either admitted due to a serious adverse drug reaction or had a serious ADR...

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Building a cohort, the easy way

Jan. 7, 2021—An automated system using keyword searches can help identify candidates for clinical trials on adverse drug reactions.

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Genes spell penicillin allergy risk

Oct. 1, 2020—Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction.

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Effort seeks to improve safety of drugs given during pregnancy

Jul. 18, 2019—A 19-year-old student is leading a multi-institutional collaboration to identify drugs that can be prescribed safely to pregnant women without harming the fetus.

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Gene identified that increases risk of antibiotic reaction

Feb. 28, 2019—Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin.

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Immunotherapies linked to specific heart complications

Nov. 15, 2018—In the first large-scale analysis of cardiovascular complications linked to immune checkpoint inhibitors, Vanderbilt researchers have shown that heart and vessel complications include myocarditis, pericarditis, vasculitis and arrhythmias, and that they occur early in the course of treatment.

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Team seeks to shed light on rare immune-mediated adverse drug reaction

May. 31, 2018—Thirty years ago when she was 16, Katie Niemeyer was prescribed carbamazepine for depression. Three weeks later she was in a St. Louis, Missouri, burn unit with second and third degree burns all over her body. “My parents were told the chances of me surviving were slim,” she said.

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Records point to drug-drug interaction

May. 7, 2018—Patients who take a cholesterol-lowering statin drug while taking the antibiotic daptomycin have increased risk of developing muscle weakness or a more severe form of muscle damage.

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Daughter’s rare adverse drug reaction inspires family’s donation

Dec. 21, 2016—Last year Paul and Wanpen Anderson of Champaign, Illinois, were preparing to celebrate the Christmas holidays with their two children when their 22-year-old daughter, Angela, developed a rare adverse drug reaction called SJS/TEN.

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