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Aliquots Archives

Risk score for muscular dystrophy

Nov. 22, 2022—An imaging-based risk score can identify patients with Duchenne muscular dystrophy who are at greater risk of early mortality, allowing more intensive treatment and potentially prolonging life.

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Suicide notes

Nov. 21, 2022—Natural language processing of notes in electronic health records can identify suicidal behavior and could be used to directly improve real-time risk prediction algorithms.

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Surgery for hereditary breast cancer

Nov. 17, 2022—Similar rates of bilateral mastectomy in women with inherited mutations in high- and moderate-penetrance genes raises concerns about possible overtreatment of some patients, Vanderbilt researchers report.

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A marker for mortality

Nov. 17, 2022—A urine biomarker of inflammation was associated with increased mortality and multiple lifestyle factors, suggesting that modifications could help reduce premature mortality.

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Alzheimer’s risk factor and cognition

Nov. 8, 2022—Vanderbilt researchers found that a protein with roles in innate immunity worsens memory at baseline in carriers of APOE-e4, the strongest genetic risk factor for Alzheimer’s disease, further implicating neuroinflammation in cognitive decline.

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Gene mutations impair gut barrier

Nov. 7, 2022—Mutations in a cell membrane transporter protein impair the integrity of the gut lining, contributing to chronic gastrointestinal distress for people with the mutations, Vanderbilt researchers report.

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C. diff infections drop in children

Nov. 3, 2022—The number of pediatric infections caused by Clostridioides difficile (C. diff) decreased from 2013 to 2019, likely due to an increase in antibiotic stewardship programs and improved hospital contact protocols, Vanderbilt researchers found.

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Social behavior brain circuitry

Nov. 3, 2022—Vanderbilt researchers have identified a novel mechanism regulating social behavior: Neuropeptide Y signaling in the nucleus accumbens brain region.

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Vascular dysfunction during sepsis

Oct. 25, 2022—Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.

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Metabolic signatures of Type 2 diabetes risk

Oct. 24, 2022—Vanderbilt epidemiologists found 32 blood metabolites associated with obesity and showed that adding these to traditional disease prediction models improves accuracy of determining Type 2 diabetes risk.

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New target for lung fibrosis

Oct. 20, 2022—Blocking thromboxane-prostanoid receptor signaling protected animals from lung fibrosis in preclinical models, suggesting a new treatment for IPF — a chronic, progressive lung disorder that often kills within 3-5 years of diagnosis.

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Aging beta cells hasten Type 2 diabetes

Oct. 20, 2022—Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.

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