Aliquots Archives
Commensal gut bacterium protects from severe intestinal infection
Nov. 21, 2023— The commensal bacterium Turicibacter sanguinis could be used to protect against severe intestinal infections, Vanderbilt researchers discovered.
Nasty microbe H. pylori has Achilles’ heel
Nov. 16, 2023—Vanderbilt researchers found that an H. pylori enzyme is essential for colonization of the stomach, suggesting it as a promising therapeutic target for H. pylori infection.
Polygenic “scores” may improve cancer screening
Oct. 31, 2023—Accounting for genetic variability in biomarkers not associated with cancer risk could avoid unnecessary diagnostic procedures, Vanderbilt researchers found.
Bone metabolism changes with aging
Sep. 14, 2023—Vanderbilt researchers have detailed how aging alters the metabolism of bone-forming cells, which could contribute to age-related osteoporosis.
Low-flow cerebrospinal fluid in Huntington’s disease: study
Sep. 7, 2023—Vanderbilt researchers found reduced net flow of cerebrospinal fluid in Huntington’s disease, which could contribute to mutant protein retention and altered responsiveness to medications delivered via the spinal cord.
New reference tool supports replication of DNA biobank studies
Aug. 31, 2023—Vanderbilt researchers created a phenotype-genotype reference map to assess data quality in DNA biobanks.
Predicting postop opioid use
Aug. 24, 2023—VUMC study finds that preoperative patient characteristics can predict daily opioid use at six months after surgery, suggesting opportunities for development of electronic risk-stratification algorithms.
Personalizing treatment for sinus syndrome
Aug. 2, 2023—Understanding the inflammatory characteristics of subtypes of chronic rhinosinusitis with polyps should assist with selection of effective therapies, Vanderbilt researchers report.
Signaling pathways in liposarcomas
Jul. 25, 2023—A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.
Rare case: brain injury stirs creativity, synesthesia
Jul. 20, 2023—Vanderbilt researchers report on a musician who acquired synesthesia — a merging of sensations — and improved creativity following a traumatic brain injury.
Novel treatments for fake patients
Jul. 7, 2023—A customizable framework uses simulated patients to distinguish effects of a new treatment from “learning effects” for clinicians; it should help identify training opportunities and hasten treatment improvements.
Rare disorder sheds light on dysbindin function
Jun. 27, 2023—A case study of a rare disorder uncovers roles for the protein dysbindin in the adaptive immune response and suggests that mutations may underlie some cases of very early onset inflammatory bowel disease.
