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Aliquots Archives

Bone metabolism changes with aging

Sep. 14, 2023—Vanderbilt researchers have detailed how aging alters the metabolism of bone-forming cells, which could contribute to age-related osteoporosis.

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Low-flow cerebrospinal fluid in Huntington’s disease: study

Sep. 7, 2023—Vanderbilt researchers found reduced net flow of cerebrospinal fluid in Huntington’s disease, which could contribute to mutant protein retention and altered responsiveness to medications delivered via the spinal cord.

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New reference tool supports replication of DNA biobank studies

Aug. 31, 2023—Vanderbilt researchers created a phenotype-genotype reference map to assess data quality in DNA biobanks.

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Predicting postop opioid use

Aug. 24, 2023—VUMC study finds that preoperative patient characteristics can predict daily opioid use at six months after surgery, suggesting opportunities for development of electronic risk-stratification algorithms.

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Personalizing treatment for sinus syndrome

Aug. 2, 2023—Understanding the inflammatory characteristics of subtypes of chronic rhinosinusitis with polyps should assist with selection of effective therapies, Vanderbilt researchers report.

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Signaling pathways in liposarcomas

Jul. 25, 2023—A broad bioinformatics approach revealed that Hedgehog signaling is upregulated in dedifferentiated liposarcoma, suggesting this pathway may be an early indicator of poor prognosis and a potential therapeutic target.

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Rare case: brain injury stirs creativity, synesthesia

Jul. 20, 2023—Vanderbilt researchers report on a musician who acquired synesthesia — a merging of sensations — and improved creativity following a traumatic brain injury.

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Novel treatments for fake patients

Jul. 7, 2023—A customizable framework uses simulated patients to distinguish effects of a new treatment from “learning effects” for clinicians; it should help identify training opportunities and hasten treatment improvements.

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Rare disorder sheds light on dysbindin function

Jun. 27, 2023—A case study of a rare disorder uncovers roles for the protein dysbindin in the adaptive immune response and suggests that mutations may underlie some cases of very early onset inflammatory bowel disease.

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Magnesium deficiency and blood pressure

Jun. 26, 2023—Dietary magnesium depletion in a mouse model activated inflammatory pathways and molecules that promote hypertension, suggesting that increased magnesium consumption may be beneficial for reducing the prevalence of hypertension.

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Pathways to a healthy liver

Jun. 22, 2023—Hepatic stellate cells maintain liver mass and function; the signaling factors they use could be exploited therapeutically to promote liver regeneration and inhibit cancerous proliferation, Vanderbilt researchers suggest.

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Mosaicism and genetic disease

Jun. 22, 2023—Genetic mosaicism — when the body’s cells do not all have the same genetic makeup — could generate variants previously thought to be spontaneous in genetic disease, and detecting parental mosaicism could clarify recurrence risk for future children.

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