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Aliquots Archives

Vascular dysfunction during sepsis

Oct. 25, 2022—Regulation of the enzyme Sirtuin 1 in blood vessel endothelial cells may drive altered metabolism and vascular dysfunction during sepsis, Vanderbilt researchers have discovered.

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Metabolic signatures of Type 2 diabetes risk

Oct. 24, 2022—Vanderbilt epidemiologists found 32 blood metabolites associated with obesity and showed that adding these to traditional disease prediction models improves accuracy of determining Type 2 diabetes risk.

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New target for lung fibrosis

Oct. 20, 2022—Blocking thromboxane-prostanoid receptor signaling protected animals from lung fibrosis in preclinical models, suggesting a new treatment for IPF — a chronic, progressive lung disorder that often kills within 3-5 years of diagnosis.

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Aging beta cells hasten Type 2 diabetes

Oct. 20, 2022—Vanderbilt investigators have found that aging induces chronic cellular stress in pancreatic beta cells, which could contribute to the development of diabetes as we age.

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Skin pigment affects oxygen monitor

Oct. 11, 2022—Black patients in the ICU were more likely to have low or high blood oxygen levels than white patients, even when a pulse oximeter indicated 92-96% oxygen saturation, Vanderbilt researchers found.

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Opening a window to glaucoma

Oct. 10, 2022—A metalloprotease enzyme plays an important role in retinal ganglion cell development, Vanderbilt researchers discovered; studying it and other family members may lead to the identification of novel targets for treating glaucoma.

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Gene tied to childhood epilepsy

Oct. 6, 2022—Data drawn from four unrelated patients with a childhood epilepsy syndrome — and from in vitro and in vivo studies — link novel variants in a GABA transporter gene to seizure activity, Vanderbilt researchers reported.

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Stress, obesity and food intake

Oct. 6, 2022—Vanderbilt researchers are elucidating the neuronal pathways that contribute to food consumption in response to stress — “comfort feeding” — and how they differ in males versus females and in the context of obesity.

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Diagnostic biomarker for bone disorder

Sep. 27, 2022—A urine chemical performs better as a diagnostic biomarker for the soft bone disease hypophosphatasia than other laboratory measures, Vanderbilt researchers have demonstrated.

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Gender differences with bladder pain

Sep. 26, 2022—Gender differences in the pain experiences and treatment needs of people with a urologic pain syndrome could be used to improve interventions, Vanderbilt researchers report.

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Reduced exercise capacity in ICU survivors

Sep. 22, 2022—ICU survivors who have impaired exercise capacity months after discharge may have damaged muscle mitochondria — the energy powerhouses of the cell, Vanderbilt researchers propose.

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Nerve cells and cancer progression

Sep. 22, 2022—Immature nerves and neural precursor cells increase in density as a type of premalignant tumor in the pancreas progresses to invasive disease, suggesting that blocking these cells may arrest malignant progression.

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