Aliquots Archives
Calculating risk for uterine fibroids
Apr. 26, 2022—Vanderbilt researchers have constructed a polygenic risk score for uterine fibroids that will be useful for exploring causes of these benign tumors and identifying novel drug targets and therapies.
Molecular testing across tumor types
Apr. 25, 2022—The KRAS inhibitor sotorasib is newly approved for one kind of lung cancer; Vanderbilt researchers ask if it should be considered for another type if the tumor has the gene mutation it targets.
When science spills onto social media
Apr. 21, 2022—Vanderbilt researchers report that social media posts can offer insights into how the public feels about genome editing, with stances varying across platforms and differing from those of academics and policy makers.
Youthful healing for burn wounds
Apr. 21, 2022—Topical treatment of burns with an immunosuppressive drug counteracted the negative effects of aging on wound healing, Vanderbilt researchers have discovered.
Financial impact of prior authorization
Apr. 12, 2022—Prior authorization — health insurer approval of a medical intervention prior to treatment — costs more than $40 million for U.S. academic radiation oncology practices, with questionable value added to patient care.
Peptides promote AFib arrhythmia
Apr. 11, 2022—Peptide oligomers have detrimental metabolic effects and cause pro-arrhythmic electrophysiological changes in heart atria, suggesting they may contribute to atrial fibrillation.
Computer eyeballs graft-vs-host disease
Apr. 7, 2022—A machine learning algorithm identified areas of skin affected by chronic graft-versus-host disease on par with clinicians, opening the door to streamlining and standardizing this measure of patient response to therapy.
New prognosis predictor and target for gastric cancer
Apr. 7, 2022—The protein CGA — a subunit of glycoprotein hormones — is a biomarker that predicts chemoresistance in gastric cancer and could be targeted along with EGFR to restore chemosensitivity.
There’s no slowing arterial stiffening
Mar. 29, 2022—Over 10 years, multiple healthy behaviors did not slow the progression of arterial stiffness, a risk factor for coronary artery disease, hypertension, stroke, atrial fibrillation and heart failure.
Rheumatoid arthritis: special deliveries
Mar. 28, 2022—Birth outcomes including postpartum infection and blood transfusion were similar in women with and without rheumatoid arthritis, and continued use of disease-modifying antirheumatic drugs and biologics is recommended to limit steroid exposure.
Stress in young adult cancer patients and caregivers
Mar. 24, 2022—Adolescent and young adult oncology patients and caregivers experience psychosocial impairment and financial toxicity at the time of cancer diagnosis, findings that will inform interventions to support patient and caregiver well-being.
Reducing obesity-related inflammation
Mar. 24, 2022—A treatment that increases levels of lipid signaling molecules reduced adipose tissue inflammation in obese adults, suggesting this pathway may be a valuable target for modulating fat and systemic inflammation.
