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Basic Sciences Archives

Protein interactions and brain function

Feb. 20, 2020—Roger Colbran and colleagues have discovered new molecular details about the function of an enzyme with a key role in shaping learning and memory.

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Transporter mutation alters cell energy

Feb. 20, 2020—A disease-associated mutation in a transporter protein causes cells to increase energy production, as if they are starving, Vanderbilt researchers have discovered.

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A key to calcium signaling

Feb. 11, 2020—Erkan Karakas and colleagues used cryo-electron microscopy to determine structural details of a calcium channel protein that has numerous cell signaling roles.

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New tool probes gene regulation

Feb. 6, 2020—Vanderbilt biochemists got unexpected results when they used their new approach to explore the role of DNA methylation in gene regulation.

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A new contributor to atherosclerosis

Jan. 27, 2020—Sean Davies and colleagues are exploring lipid aldehydes produced during oxidative stress and their contribution to HDL dysfunction and atherosclerosis.

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Insights on diabetic retinopathy

Jan. 23, 2020—A drug that targets multiple pathogenic steps in diabetic retinopathy may be an ideal therapeutic strategy for the disease, Vanderbilt researchers report.

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Vanderbilt-led team discovers new genetic disease and defines underlying mechanism

Jan. 13, 2020—An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms.

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Structural views of a C. diff toxin

Jan. 10, 2020—D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.

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Reversing stress-related anxiety

Dec. 20, 2019—Inhibiting COX-2 — an enzyme associated with inflammation — could provide a novel therapeutic approach for stress-related psychiatric disorders.

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Cell fate signaling

Dec. 17, 2019—A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

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Protein dynamics in the beating heart

Dec. 16, 2019—To study the dynamics of structural proteins in the heart, Vanderbilt investigators generated a cellular tool they expect will be useful for screening drugs that affect heart muscle contraction.

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Genetic screen in worms reveals critical step in insulin synthesis

Dec. 4, 2019—The identification of a protein important for insulin synthesis may hold clues for understanding the pathogenesis of diabetes.

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Recent Stories from VUMC News and Communications Publications

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer.  Don’t hesitate. Do it.

Momentum

Betsy Williams has firsthand advice for parents on the fence about whether their adolescent children should be vaccinated for the common human papilloma virus (HPV), which can lead to six types of cancer. Don’t hesitate. Do it.

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

Vanderbilt Medicine

Keeping pace: Nashville, once a mid-size city with a Southern small-town feel, is experiencing explosive growth.

VUMC campus

VUMC campus

Vanderbilt University School of Medicine entrance

Vanderbilt University School of Medicine entrance

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