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Blood Archives

Researchers clarify role of blood cell mutations in disease

Feb. 2, 2023—Vanderbilt researchers have developed a new method to analyze mutations in blood stem cells that can trigger explosive, clonal expansions of abnormal cells.

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Breast cancer biomarkers of response

Jun. 16, 2022—Vanderbilt researchers have identified blood-based biomarkers associated with complete responses to neoadjuvant chemotherapy in patients with breast cancer.

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Treating severe trauma requires a robust blood supply; VUMC employees and public urged to donate blood now

Dec. 1, 2021—To understand the implications of the current, ongoing national blood shortage, which acutely deteriorated after the Thanksgiving holiday, VUMC employees need only to consider what the shortfall means to their own Level 1 Trauma Center…and potentially to them or their loved ones, said Oscar Guillamondegui, MD, MPH, Chief, Division of Trauma and Surgical Critical Care....

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Cell death pathway implicated in bone marrow failure

Jan. 31, 2019—Vanderbilt investigators have linked a specific form of programmed cell death to myelodysplastic syndrome, a type of bone marrow failure.

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Plasma study proves increased survival rate of critically injured patients

Sep. 27, 2018—by Kristin Smart  A Vanderbilt University Medical Center study has found that giving fresh, frozen plasma to critically injured patients in hemorrhagic shock during medical helicopter transport decreased their need for blood transfusions and improved survival.    VUMC enrolled 97 patients in this four-year study; 42 received plasma, and 55 received standard care. After 30 days,...

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How Epo action is ‘enhanced’

Jul. 24, 2017—The hormone erythropoietin (Epo) controls red blood cell production and synthetic forms of Epo treat multiple disorders. New Vanderbilt research details how Epo works.

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Risk of death in sickle cell disease

Feb. 22, 2017—Two factors commonly used to evaluate patients with sickle cell disease are associated with each other and can predict increased mortality, Vanderbilt researchers have discovered.

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Hhex on cancer

Jul. 13, 2015—A new mouse model demonstrates that the Hhex gene – which is linked to blood cancers – is critical for normal blood cell production.

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Kids more likely to react to blood transfusions

May. 4, 2015—Pediatric patients have a significantly higher incidence of transfusion reactions compared to adults, according to a study by Vanderbilt University researchers.

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Streptococcus virulence involves three-step plasminogen binding

Mar. 20, 2015—Researchers at Vanderbilt have shown for the first time how a component of streptococci A and C bacteria helps spread the virus so rapidly through the body.

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Linking oxygen, iron and red blood cells

Feb. 6, 2013—The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance.

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Bid protein guards blood cells against stress

Oct. 25, 2012—A protein normally known to promote cell death found to encourage survival of blood forming cells.

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