cancer biology Archives
Protein “pockets” help ID cancer genes
Nov. 11, 2014—Vanderbilt investigators have used a computational biology approach to uncover new cancer drivers and biomarkers of anticancer drug response.
Immune cell activity and melanoma
Nov. 6, 2014—The activity of a certain factor in immune cells is essential for an anti-tumor response, emphasizing the need to consider the effects of anti-cancer therapies on immune cells.
Potential therapy for postpartum breast cancer investigated
Oct. 30, 2014—Nearly 25 percent of all breast cancers among premenopausal women occur within two to five years following a pregnancy.
Long-range signaling to stem cells
Oct. 9, 2014—The potential for long-range signaling factors – such as those identified in the current study – to regulate stem cell behaviors has implications in tumor progression and metastasis.
VU study reveals shared pathways in psychiatric disorders
Sep. 18, 2014—Schizophrenia and bipolar disorder share common genetic underpinnings. Vanderbilt researchers combined high-resolution gene expression studies with gene association data to reveal signaling pathways linked to schizophrenia and bipolar disorder.
Bone healing therapy for NF1 fractures
Sep. 11, 2014—A combination treatment delivered to the site of fractures may improve bone healing in patients with the genetic disease neurofibromatosis type-1.
Limiting breast cancer metastasis
Aug. 28, 2014—Vanderbilt researchers have identified a new target for blocking breast cancer metastasis.
Growth factor blockade targets breast tumors
Aug. 14, 2014—Inhibition of BMP growth factor signaling reduces breast tumor burden and metastasis.
Novel treatment strengthens bones in genetic disease
Aug. 7, 2014—An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered.
Drug discovery clues in network map
Aug. 5, 2014—Vanderbilt investigators have constructed a network map that could guide the development of new targeted cancer therapies.
Repair protein’s DNA recognition motif
May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.
Potential mechanism for myeloma drug’s variable toxicity
Apr. 30, 2014—A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication.
