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cancer biology Archives

New drugs a good BET for brain cancer

Mar. 20, 2013—A novel class of drugs that target “BET” proteins may have broad utility for treating genetically diverse brain tumors.

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Linking oxygen, iron and red blood cells

Feb. 6, 2013—The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance.

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Brain tumor TIP reveals new target

Feb. 4, 2013—The protein TIP-1 appears to be a novel prognostic marker for glioblastoma and may be a good therapeutic target for disrupting tumor-driven blood vessel development.

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Do-it-yourself repair in the kidney

Jan. 31, 2013—The kidney can mediate its own repair through proliferation of resident immune system cells.

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A drug combo for ovarian cancer

Dec. 24, 2012—Combining another drug with platinum-based chemotherapies may be more effective against ovarian cancer.

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Study tracks antioxidants’ role in prostate tumor growth

Nov. 15, 2012—Antioxidants promote cell growth in a mouse model of prostate cancer, Vanderbilt researchers report in the journal PLoS ONE. The findings provide insight into the recent controversy regarding antioxidants and prostate cancer prevention.

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Stomach bug alters tumor suppressor

Oct. 23, 2012—The stomach bug Helicobacter pylori increases forms of a protein that promote tumor development, perhaps explaining how it elevates risk for gastric cancer.

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Proteins help flip tumor’s invasive switch

Oct. 4, 2012—Vanderbilt investigators have identified how two key components of cancer's invasive "switch" — the series of signaling events that turn on a tumor cell’s invasive behavior — work together.

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Target acquired for aggressive tumor

Sep. 27, 2012—New therapeutic target for angiosarcoma – an aggressive, highly fatal tumor of the blood vessels – identified.

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Cells with LIP eat their neighbors

Sep. 13, 2012—A transcription factor called LIP is capable of causing one cell to consume another.

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Enzyme counters stomach acid attack

Sep. 11, 2012—Dysfunction or loss of an “antioxidant” enzyme may lead to higher risk for esophageal cancer in patients with gastric reflux disease.

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Gene linked to familial prostate cancer

Aug. 23, 2012—A rare, inherited mutation confers an eightfold increased risk of prostate cancer, a recent study shows.

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