cancer Archives
Fleming reflects on a life of love, purpose as its end nears
Jun. 4, 2020—A month before his 49th birthday, Geoffrey Fleming, MD, had a biopsy of his liver to diagnose an unidentified metastatic disease that he already knew was “something bad.”
Multinational consortium reports COVID-19 impact on cancer patients
May. 28, 2020—People with cancer sickened by COVID-19 have a crude death rate of 13%, according to the largest series of data released thus far from a multinational perspective. The data on more than 900 patients, published May 28 in The Lancet and simultaneously presented at ASCO20 Virtual, also revealed cancer-specific factors associated with increased mortality.
Probing innate immunity
May. 19, 2020—Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA.
Imaging breast cancer cell size
Feb. 10, 2020—A noninvasive MRI approach assesses breast tumor cell size and could be a useful way to evaluate early response to neoadjuvant therapy.
Cell fate signaling
Dec. 17, 2019—A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.
Understanding cell division
Nov. 18, 2019—Vanderbilt researchers have uncovered another piece in the puzzle of how cells divide — a process that goes awry in cancer cells.
A “rheostat” for cancer signals
Aug. 27, 2019—Jason MacGurn and colleagues have characterized a “rheostat” that sets WNT pathway signaling in breast cancer cells.
Cancer susceptibility genes
Aug. 26, 2019—Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.
New window on fibrosis
Aug. 8, 2019—A previously unrecognized role for a cell surface receptor may open new therapeutic options for the treatment of fibrotic diseases.
Team’s study reveals details of new DNA repair pathway
Jul. 25, 2019—Investigators have discovered how a DNA repair pathway protein shields sites of damage to avoid mutations and maintain genome integrity.
Mouth microbes and colorectal cancer
Jun. 6, 2019—Microbial species in the mouth could be playing a role in colorectal cancer development, according to new research from epidemiologists at VUMC.
Study details regulation of a multi-drug transporter
May. 29, 2019—P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
