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Clinical Cancer Research Archives

Study identifies biomarker for breast cancer response to immunotherapy

Aug. 12, 2021—A biomarker that has proven to be a predictor for response to immunotherapies in melanoma patients also has clinical relevance for breast cancer patients, according to a new study published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

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Study explores melanoma drug’s effectiveness

Apr. 23, 2020—A study by Vanderbilt research-ers supports the clinical development of a new second-line treatment for metastatic melanoma.

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Breast cancer study may help predict treatment response

Feb. 27, 2020—Researchers at VUMC are reporting another advance in the understanding and treatment of triple-negative breast cancer, which is particularly aggressive and difficult to treat.

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Study finds breast cancer recurrence score has different implications for men

Nov. 20, 2019—A study published last year offered good news for women with early-stage ER-positive breast cancer who scored at intermediate risk for recurrence. However, a new study finds this conclusion may not directly apply to male patients with the same type of breast cancer

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Study reframes approach to targeted therapy resistance

Apr. 11, 2019—When a tumor mutates and develops resistance to a targeted therapy, researchers often focus on the acquisition of new mutations within the drug target as they seek an alternative treatment, but a team of Vanderbilt scientists has shown this may not be sufficient.

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Improving therapies for GI tumors

Feb. 20, 2017—A signaling protein overexpressed in upper gastrointestinal cancers is an attractive therapeutic target.

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Drug combos for glioblastoma

May. 3, 2016—Vanderbilt researchers have discovered that activation of a certain signaling pathway protects brain cancers from targeted therapies, suggesting that using therapeutics that block both pathways may be a promising treatment.

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Five candidates sought for Runyon Cancer Clinical Investigator Award

Nov. 13, 2015—Vanderbilt University may nominate five candidates for the 2016 Damon Runyon Cancer Research Foundation Clinical Investigator Award.

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PET probe detects dying tumor cells

May. 8, 2014—A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine.

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New drugs a good BET for brain cancer

Mar. 20, 2013—A novel class of drugs that target “BET” proteins may have broad utility for treating genetically diverse brain tumors.

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New drug mutes more melanomas

Apr. 26, 2012—An experimental melanoma drug may be beneficial for patients not eligible for targeted therapies.

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Factor sensitizes cancer to radiation

Apr. 6, 2012—Measuring levels of an enzyme in head and neck tumors may indicate how the tumor will respond to radiation therapy.

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