Clostridium difficile Archives
Structural views of a C. diff toxin
Jan. 10, 2020—D. Borden Lacy and colleagues used cryo-electron microscopy to define the structure of a C. diff toxin, providing a framework for the design of novel therapeutics.
Treating C. diff: new purpose for an old drug?
Sep. 24, 2019—An inexpensive generic drug once used to prevent gastrointestinal ulcers in people taking daily NSAIDs protects against C. diff infection in mice.
Pain relievers a risk for C. diff?
Jan. 17, 2019—A link between anti-inflammatory drugs such as ibuprofen and C. diff infection suggests caution against overusing such drugs in patients at high risk for infection.
Grant bolsters study of potential new therapy for C. diff infection
Mar. 22, 2018—According to the Centers for Disease Control and Prevention, in 2011 in the United States there were almost half a million Clostridium difficile infections, and one in 11 patients 65 or older with a healthcare-associated C. diff infection died within 30 days of diagnosis.
Clue to recurrent C. diff infection
May. 1, 2017—Children who experience recurrent C. diff infections may have fecal inflammatory markers that could predict risk and improve management of these infections.
Crystal structure reveals secrets of virulent bacterium
Jan. 14, 2016—Researchers at Vanderbilt University Medical Center have obtained the crystal structure of a toxin from the bacterium Clostridium difficile (“C. diff”) — the leading cause of hospital-acquired diarrhea in the United States.
Skaar receives American Asthma Foundation award
Aug. 6, 2015—Eric Skaar, Ph.D., MPH, the Ernest W. Goodpasture Professor of Pathology, has received a Scholar Award from the American Asthma Foundation (AAF).
Study identifies C. diff toxin receptor, suggests new treatment approaches
Jun. 4, 2015—Vanderbilt University investigators have identified a cellular receptor for a toxin from Clostridium difficile (“C. diff”) — the leading cause of hospital-acquired diarrhea in the United States.
Defusing ‘C. diff’ infection
Nov. 8, 2013—Clostridium difficile (“C. diff”) infection is a leading cause of hospital-associated diarrhea, and the frequency and severity of infections are on the rise. D. Borden Lacy, Ph.D., associate professor of Pathology, Microbiology and Immunology, and colleagues recently demonstrated that the C. difficile toxin, TcdB, induces rapid cell death of human colon cell lines and pig colonic...
