Department of Veterans Affairs Archives
Obesity negates beneficial drug effects
Nov. 8, 2018—A drug that improves levels of “good” cholesterol may not be beneficial for obese individuals, Vanderbilt researchers have discovered.
Targeting diabetic kidney disease
Oct. 12, 2018—Pathways activated by the epidermal growth factor receptor may be attractive targets to treat diabetic kidney disease, according to new findings from Vanderbilt investigators.
Fat tissue’s “iron sink”
Sep. 27, 2018—Alyssa Hasty and colleagues demonstrated that immune cells called macrophages act in fat tissue to store iron and prevent iron toxicity.
Diabetes drug may prevent cancer
Sep. 14, 2018—The research suggests that metformin should be further studied clinically for the prevention of liver cancer.
New histoplasmosis risk map
Sep. 14, 2018—The new mapping approach, called suitability score mapping, should improve public health assessments and interventions for geographic-specific infections.
YAP after acute kidney injury
Aug. 16, 2018—Activation of the signaling protein YAP may be a target for treating acute kidney injury, which affects up to 20 percent of hospitalized patients.
Team explores diabetes drug’s ability to treat RSV infection
Jul. 12, 2018—A drug used to treat diabetes may point to new therapies for respiratory syncytial virus (RSV) bronchiolitis — inflammation and obstruction of the lungs’ small airways. A multi-disciplinary team of Vanderbilt investigators has demonstrated that liraglutide reduces the inflammatory response to RSV infection in a mouse model of the disease.
SMAD4 clue to colon cancer
Jul. 2, 2018—Loss of a gene that is part of the TGF-beta signaling pathway increased inflammation in the colon and was observed in half of human colitis-associated cancers.
Confronting TB resistance
Jun. 11, 2018—Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis.
Toxin floats on lipid rafts
Apr. 23, 2018—The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells.
Lung diseases share molecular signature
Apr. 5, 2018—Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention.
Alzheimer’s proteins in ICU survivors
Mar. 27, 2018—The cognitive impairment that affects patients who survive a stay in the ICU does not appear to have a similar mechanism to Alzheimer’s disease, Vanderbilt researchers have discovered.
