DNA replication Archives
Copying chromosome caps
Jan. 8, 2016—Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.
Study helps clarify components of DNA ‘copy machine’
Nov. 12, 2015—Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery.
Study reveals how protein helps cells tolerate DNA damage
Jul. 16, 2015—Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage.
Repair protein’s DNA recognition motif
May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.
Bypassing DNA damage
May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.
VU study sheds new light on DNA replication
Nov. 7, 2013—David Cortez, Ph.D., and his Vanderbilt colleagues report new findings that shed light on fundamental processes involved in DNA replication and have implications for cancer therapies that target these processes.
New view of DNA processing ‘hub’
Jan. 23, 2013—Structural studies reveal a new framework for understanding a central player in DNA processing.
iPOND method goes fishing for proteins
Mar. 19, 2012—A new tool will allow researchers to identify proteins involved in DNA replication and damage repair, processes that go awry in cancer.
