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drug resistance Archives

New prognosis predictor and target for gastric cancer

Apr. 7, 2022—The protein CGA — a subunit of glycoprotein hormones — is a biomarker that predicts chemoresistance in gastric cancer and could be targeted along with EGFR to restore chemosensitivity.

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VUMC mourns loss of noted scientist, teacher Stratton

Mar. 29, 2022—Charles Stratton IV, MD, associate professor of Pathology, Microbiology & Immunology and of Medicine at Vanderbilt University Medical Center, died March 21 in Nashville. He was 77.

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Melanoma treatment response

Feb. 24, 2022—Targeting the interaction between melanoma and immune cells could improve responses to targeted cancer therapies, Vanderbilt researchers found.

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Study explores how bacteria become drug resistant

Jan. 6, 2022—Vanderbilt researchers have revealed more of the inner-workings of a two-stage “molecular motor” in the cell membrane that enables bacteria to become resistant to drugs.

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Study details regulation of a multi-drug transporter

May. 29, 2019—P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.

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Evading cell death

Nov. 8, 2018—Stress granules that form in response to cellular stress help cancer cells survive and develop resistance to treatment.

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Fueling the MATE transporter

Jul. 19, 2018—Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.

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Confronting TB resistance

Jun. 11, 2018—Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis.

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“Idling” cancer cells may return

Apr. 11, 2018—Vanderbilt investigators have discovered that cancer treatment induces an “idling” state for cells, which could promote resistance to treatment.

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Researchers find novel mechanism of resistance to anti-cancer drugs

Oct. 17, 2017—Vanderbilt investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings, reported this week in Nature Medicine, suggest a strategy for overcoming this resistance.

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New test rapidly identifies cause of blood infections

May. 4, 2017—Last month, Vanderbilt Clinical Laboratories introduced rapid molecular diagnostic testing to more quickly identify microorganisms that may be causing a patient’s bloodstream infection, along with the organism’s susceptibility to drugs.

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Overcoming lung cancer drug resistance

Feb. 10, 2016—Vanderbilt investigators have discovered a way to overcome the resistance of some lung cancers to certain targeted therapies, which could lead to more effective treatments for lung cancer patients.

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