drug resistance Archives
Study details regulation of a multi-drug transporter
May. 29, 2019—P-glycoprotein distinguishes between chemicals that it will expel from a cell and inhibitors that block its action.
Evading cell death
Nov. 8, 2018—Stress granules that form in response to cellular stress help cancer cells survive and develop resistance to treatment.
Fueling the MATE transporter
Jul. 19, 2018—Vanderbilt researchers used spectroscopy to understand how a drug transporter pumps drugs out of cells, findings that are important for developing novel anti-cancer and anti-bacterial drugs that can overcome drug resistance.
Confronting TB resistance
Jun. 11, 2018—Vanderbilt researchers describe how certain tuberculosis treatments work and suggest these medications may overcome the threat of drug-resistant tuberculosis.
“Idling” cancer cells may return
Apr. 11, 2018—Vanderbilt investigators have discovered that cancer treatment induces an “idling” state for cells, which could promote resistance to treatment.
Researchers find novel mechanism of resistance to anti-cancer drugs
Oct. 17, 2017—Vanderbilt investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings, reported this week in Nature Medicine, suggest a strategy for overcoming this resistance.
New test rapidly identifies cause of blood infections
May. 4, 2017—Last month, Vanderbilt Clinical Laboratories introduced rapid molecular diagnostic testing to more quickly identify microorganisms that may be causing a patient’s bloodstream infection, along with the organism’s susceptibility to drugs.
Overcoming lung cancer drug resistance
Feb. 10, 2016—Vanderbilt investigators have discovered a way to overcome the resistance of some lung cancers to certain targeted therapies, which could lead to more effective treatments for lung cancer patients.
Dynamics of a drug resistance transporter
Feb. 5, 2016—Vanderbilt investigators are exploring the shape changes in a multidrug transporter to understand the mechanisms of antibacterial resistance.
New lead for ovarian cancer treatment
Dec. 10, 2015—Combining inhibitors of the BMP signaling pathway with standard chemotherapy drugs may overcome drug resistance in ovarian cancer.
Detect and defend against pathogens
Nov. 4, 2015—Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.
Targeting HIV’s “cap”
Feb. 10, 2015—New findings underscore the attractiveness of the HIV capsid – the structure that encloses the viral genome – as a therapeutic target.
