Microvilli in motion
Sep. 19, 2019—Live cell imaging studies have revealed that microvilli — finger-like protrusions on the surface of epithelial cells — move and collide as they form the brush border.
Protein loss promotes cell migration
Feb. 28, 2019—The protein kinase STK17A plays a novel role in epithelial cells and its loss may contribute to colorectal cancer invasion and metastasis, Vanderbilt researchers report.
Cell skeleton and the brush border
Jan. 31, 2018—Vanderbilt researchers have discovered a role for microtubules — part of the cellular “skeleton” — in organizing the unique sidedness of the epithelial cells that line organs like the intestines.
Polarity protein suppresses tumor growth, invasion
Nov. 29, 2012—The machinery that builds the characteristic shape of epithelial cells suppresses breast cancer formation and metastasis in a mouse model.
Intestinal artillery launches anti-bacterial attack
May. 14, 2012—The epithelial cells that line the intestines have a newly discovered mechanism for protecting us against microbes: they fire anti-bacterial "bullets" into the gut.
Protein combos keep cells straight
Mar. 18, 2011—Researchers define the protein interactions that establish our organs' lining.