F Guengerich Archives
Steroid binding to metabolic enzyme
Jun. 12, 2019—Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer.
Altered metabolism and disease
Jul. 25, 2017—Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone.
Faulty building blocks in DNA
Jan. 22, 2016—An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations.
Rational design of novel antifungals
Oct. 7, 2015—Structural and molecular details of an anti-fungal target's interaction with inhibitors suggest ways to design better treatments for fungal infections.
How the cell makes morphine
Aug. 25, 2015—Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine.
Bypassing DNA damage
May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.
Carcinogenic chemicals cramp DNA
Nov. 21, 2012—Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.
An orphan enzyme’s purpose
Oct. 4, 2012—“Orphan” enzyme may play role in cancer growth, new research suggests.
DNA: From modification to mutation
Jun. 8, 2012—Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation.
