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fat Archives

Study may lead to new diabetes, heart disease treatments

Jan. 12, 2023—Vanderbilt research found that deletion of an autophagy-participating factor named PIK3C3 from the fat cells of mice led to compromised body temperature control, abnormal blood lipid levels, fatty liver and diabetes.

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Regulators of fat cell metabolism

Sep. 7, 2021—Vanderbilt researchers have discovered new details of the regulation of fat cell metabolism, findings that are important for combating obesity.

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Study reveals missing link between high-fat diet, microbiota and heart disease

Aug. 12, 2021—A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.

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HIV, diabetes and immune cells in fat

Mar. 18, 2021—In HIV-positive individuals with diabetes, immune cells in fat are more proinflammatory and cytotoxic and may represent a therapeutic target for diabetes.

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Fat tissue’s “iron sink”

Sep. 27, 2018—Alyssa Hasty and colleagues demonstrated that immune cells called macrophages act in fat tissue to store iron and prevent iron toxicity.

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Enzyme protects against obesity-related heart disease

Jun. 7, 2018—Vanderbilt scientists have discovered that a certain enzyme plays a crucial role in preventing obesity-related cardiac dysfunction.

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Fat hormone’s role in zebrafish

Mar. 8, 2016—The hormone leptin regulates glucose balance, but not fat stores, in zebrafish.

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Study examines therapeutic bacteria’s ability to prevent obesity

Jul. 17, 2014—Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered.

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‘Yo-yo dieting’ inflames fat tissue

Aug. 9, 2013—Gaining and losing weight during “yo-yo dieting” may contribute to an exaggerated immune response in fat tissue that increases metabolic dysfunction more than steady weight gain alone.

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Gene’s impact on ‘good’ cholesterol could affect heart disease risk

Jul. 12, 2012—A genetic variant may help keep an individual’s “good” cholesterol in check.

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Mouse study offers clues for childhood obesity

Apr. 13, 2011—An obesity-associated genetic variation makes fatty food more rewarding yet less satisfying, new research in mice suggests.

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