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G protein-coupled receptors Archives

Releasing a brake that drives obesity and diabetes

Sep. 6, 2023—Vanderbilt researchers have uncovered a potential new way to help curb the rapidly rising worldwide prevalence of metabolic disorders, including obesity and diabetes.

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Cell fate signaling

Dec. 17, 2019—A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.

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The arrestin-GPCR connection

Apr. 11, 2019—Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.

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New view of dopamine heteromers

Jan. 23, 2015—Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.

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VU researchers report G protein advancement that could lead to more effective drugs

Dec. 2, 2013—Thanks in part to a computer program named “Rosetta,” Vanderbilt University researchers are closer to understanding how the ubiquitous G protein is activated – a discovery that could lead to the design of more specific and effective drugs.

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Seeing light receptor’s interactions

Jan. 18, 2013—Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development.

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Hamm’s research honored by Dutch pharmacology society

Oct. 25, 2012—Heidi Hamm, Ph.D., chair of the Department of Pharmacology, has won the 2012 Ariens Award from the Dutch Pharmacological Society.

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Nobel in Chemistry reveals VU ties that bind

Oct. 18, 2012—Several Vanderbilt researchers have collaborated with this year's Nobel Chemistry winners.

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