G protein-coupled receptors Archives
Releasing a brake that drives obesity and diabetes
Sep. 6, 2023—Vanderbilt researchers have uncovered a potential new way to help curb the rapidly rising worldwide prevalence of metabolic disorders, including obesity and diabetes.
Cell fate signaling
Dec. 17, 2019—A newly identified protein interaction that affects cell cycle regulation may be an attractive target for cancer therapy.
The arrestin-GPCR connection
Apr. 11, 2019—Understanding details of how arrestins deactivate signaling by G-protein coupled receptors is key to the design of new therapeutics aimed at these cellular "inboxes" that are targeted by up to half of all pharmaceuticals.
New view of dopamine heteromers
Jan. 23, 2015—Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist.
VU researchers report G protein advancement that could lead to more effective drugs
Dec. 2, 2013—Thanks in part to a computer program named “Rosetta,” Vanderbilt University researchers are closer to understanding how the ubiquitous G protein is activated – a discovery that could lead to the design of more specific and effective drugs.
Seeing light receptor’s interactions
Jan. 18, 2013—Understanding how the main receptor for light interacts with other signaling molecules may inform new pharmaceutical development.
Hamm’s research honored by Dutch pharmacology society
Oct. 25, 2012—Heidi Hamm, Ph.D., chair of the Department of Pharmacology, has won the 2012 Ariens Award from the Dutch Pharmacological Society.
Nobel in Chemistry reveals VU ties that bind
Oct. 18, 2012—Several Vanderbilt researchers have collaborated with this year's Nobel Chemistry winners.
