GABA Archives
Gene tied to childhood epilepsy
Oct. 6, 2022—Data drawn from four unrelated patients with a childhood epilepsy syndrome — and from in vitro and in vivo studies — link novel variants in a GABA transporter gene to seizure activity, Vanderbilt researchers reported.
Common mechanism found for diverse brain disorders: study
Jun. 23, 2021—Researchers at Vanderbilt University Medical Center have identified a common mechanism underlying a spectrum of epilepsy syndromes and neurodevelopmental disorders, including autism, that are caused by variations in a gene encoding a vital transporter protein in the brain.
Team discovers one more piece to the autism puzzle
Oct. 3, 2019—Vanderbilt investigators have linked genetic mutations in a single receptor to epilepsy, autism and intellectual disability.
Heat a trigger for seizures
Sep. 6, 2017—Elevated body temperature alone can increase vulnerability to fever-induced seizures, even in the absence of infection or inflammation.
Protein structure and epilepsy severity
Nov. 10, 2016—Understanding how mutations affect the structure and function of inhibitory neurotransmitter receptors will shed light on the mechanisms underlying some types of epilepsy.
Culprits in genetic epilepsies
Oct. 11, 2016—Genetic variation in GABA-A receptors confers risk for inherited forms of epilepsy.
Seizure mutation impairs receptor
Sep. 30, 2014—Defects in the production of certain receptors are linked to the pathogenesis of genetic epilepsies and fever-induced seizures.
Neuronal subtypes in genetic disorder
Sep. 6, 2012—Inhibitory neurons that connect and regulate signaling in the brain (interneurons) may contribute to epilepsy and autism in patients with tuberous sclerosis complex.
Probing epilepsy’s molecular sparks
May. 10, 2012—Understanding how mutations in neuronal receptors contribute to epilepsy could lead to improved therapies.
