Skip to main content

GABA Archives

Gene tied to childhood epilepsy

Oct. 6, 2022—Data drawn from four unrelated patients with a childhood epilepsy syndrome — and from in vitro and in vivo studies — link novel variants in a GABA transporter gene to seizure activity, Vanderbilt researchers reported.

Read more


Common mechanism found for diverse brain disorders: study

Jun. 23, 2021—Researchers at Vanderbilt University Medical Center have identified a common mechanism underlying a spectrum of epilepsy syndromes and neurodevelopmental disorders, including autism, that are caused by variations in a gene encoding a vital transporter protein in the brain.

Read more


Team discovers one more piece to the autism puzzle

Oct. 3, 2019—Vanderbilt investigators have linked genetic mutations in a single receptor to epilepsy, autism and intellectual disability.

Read more


Heat a trigger for seizures

Sep. 6, 2017—Elevated body temperature alone can increase vulnerability to fever-induced seizures, even in the absence of infection or inflammation.

Read more


Protein structure and epilepsy severity

Nov. 10, 2016—Understanding how mutations affect the structure and function of inhibitory neurotransmitter receptors will shed light on the mechanisms underlying some types of epilepsy.

Read more


Culprits in genetic epilepsies

Oct. 11, 2016—Genetic variation in GABA-A receptors confers risk for inherited forms of epilepsy.

Read more


Seizure mutation impairs receptor

Sep. 30, 2014—Defects in the production of certain receptors are linked to the pathogenesis of genetic epilepsies and fever-induced seizures.

Read more


Neuronal subtypes in genetic disorder

Sep. 6, 2012—Inhibitory neurons that connect and regulate signaling in the brain (interneurons) may contribute to epilepsy and autism in patients with tuberous sclerosis complex.

Read more


Probing epilepsy’s molecular sparks

May. 10, 2012—Understanding how mutations in neuronal receptors contribute to epilepsy could lead to improved therapies.

Read more


Recent Stories from VUMC News and Communications Publications

Vanderbilt Medicine
Hope
Momentum
VUMC Voice

more