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gastric cancer Archives

Grant supports research to study gastric cancer origins

Sep. 1, 2022—Vanderbilt researchers have received $5 million in funding from a new initiative by the National Cancer Institute that aims to define how gastric and gastroesophageal junction adenocarcinomas form and evolve at the cellular level.

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Study reveals how gastric cancer forms, suggests preventive treatment

Jun. 23, 2022—Eunyoung Choi, PhD, assistant professor of Surgery, and colleagues identified for the first time that Trop2+/CD133+/CD166+ dysplastic stem cells are a key source of clonal evolution of dysplasia to multiple types of gastric cancer.

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Choi, Short receive AGA Research Foundation Awards

Jun. 2, 2022—Two Vanderbilt researchers have received awards from the AGA Foundation, the charitable arm of the American Gastroenterological Association.

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New prognosis predictor and target for gastric cancer

Apr. 7, 2022—The protein CGA — a subunit of glycoprotein hormones — is a biomarker that predicts chemoresistance in gastric cancer and could be targeted along with EGFR to restore chemosensitivity.

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H. pylori, lipid loss and stomach cancer

Jan. 17, 2022—H. pylori infection — a strong risk factor for stomach cancer — changes the composition of stomach lipids, which could offer new biomarkers for detecting premalignant changes, Vanderbilt researchers discovered.

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Oral microbes and gastric cancer

Dec. 13, 2021—Studies in three large population cohorts that include Asian, African American and European American people support a role for the oral microbiota — the collection of microbial species in the mouth — in gastric cancer development.

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New marker for metaplasia

Oct. 14, 2021—A protein that transports water, called aquaporin 5, is expressed by cells undergoing changes that may increase risk for gastric cancer development, Vanderbilt researchers discovered.

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Study finds genetic factor undermines H. pylori treatment

Aug. 4, 2021—Helicobacter pylori, a stomach-dwelling bacterium, is a strong risk factor for gastric cancer, peptic ulcers and other debilitating gastrointestinal disorders. Yet efforts to eradicate it using a combination of antibiotics and proton pump inhibitors (PPIs), which suppress gastric acid production, often fail.

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Study gauges specific site stomach cancer risks among ethnic groups

Aug. 6, 2020—Non-white Americans, especially Asian Americans, are at disproportionately higher risk for gastric cancer compared to non-Hispanic white Americans. A new study breaks down this risk according to specific ethnicities and locations within the stomach.

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Stomach bug hit-and-run

Jul. 23, 2020—The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate.

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Researcher works on protocols to implement screening for gastric cancer

Apr. 2, 2020—A Vanderbilt gastroenterologist is helping lead an effort to establish screening guidelines for gastric cancer in the United States, where the number of people at risk for the cancer is increasing as the nation’s population becomes more diverse.

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Powering H. pylori pathogenesis

Feb. 6, 2020—Timothy Cover and colleagues report new insights into the sources of energy used by a bacterial “machine” linked to the pathogenesis of stomach cancer.

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