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gene expression Archives

Gene network linked to Type 2 diabetes

May. 5, 2022—Vanderbilt researchers used a novel analytical approach to identify a network of genes associated with Type 2 diabetes, including 31 genes that had not previously been associated with the disease.

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Expression atlas for cell regulators

Aug. 19, 2021—Vanderbilt researchers report a comprehensive tissue-specific atlas of protein and mRNA expression for p63 and p73, members of the p53 family signaling network that is the most frequent target of mutations in human cancers.

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Study finds that regulatory protein prevents signaling that triggers cell death

May. 6, 2021—A protein implicated in neurodegenerative diseases including amyotrophic lateral sclerosis prevents the activation of an innate immune response that leads to cell death, Vanderbilt researchers have discovered.

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Gene network for leukemia factor

Feb. 4, 2021—A new method speeds the analysis of factors that control gene expression from days to minutes, allowing researchers to uncover new targets for cancer treatment.

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New tool to probe genetic mechanisms of disease

Oct. 22, 2020—Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.

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Grant from Google to support COVID gene expression study

Sep. 17, 2020—Vanderbilt University Medical Center and the University of North Carolina (UNC) at Chapel Hill have been awarded $500,000 by Google’s philanthropy, Google.org, to study how COVID-19 alters gene expression in some people in ways that may be linked to their risk of severe illness and death.

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New predictors of prostate cancer risk

Sep. 17, 2020—An international group of researchers including Vanderbilt epidemiologists has identified new DNA methylation biomarkers associated with prostate cancer risk.

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Cancer susceptibility genes

Aug. 26, 2019—Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.

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Probing H. pylori cancer protein

Feb. 14, 2019—Understanding how a bacterial protein that influences the risk of stomach cancer is produced could guide new strategies for treatment.

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Team seeks to create gene expression map of worm’s nervous system

Dec. 6, 2018—How do you build a brain? What “rules” govern where neurons end up, how they connect to each other, and which functions they perform?

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Energetic gene switch

Aug. 30, 2018—New findings link flux through glycolysis, which produces cellular energy, with transcription and gene expression via histone modification.

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Predictive models for gene regulation

Aug. 16, 2018—Using new computational approaches to understand the behavior of cells should aid efforts to predict how mutations affect cell function and how diseases respond to drug combinations.

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