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gut Archives

Study sheds light on human gut’s ‘pacemaker’ cells

Jul. 30, 2015—The gut has its own built-in pacemakers, populations of specialized cells that control smooth muscle contraction in the stomach, small intestine and colon.

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Nutrient-absorbing surface’s assembly revealed: study

Apr. 17, 2014—Vanderbilt University researchers have discovered how intestinal cells build the "brush border" -- a specialized surface structure that is critical for absorbing nutrients and defending against pathogens.

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Defusing ‘C. diff’ infection

Nov. 8, 2013—Clostridium difficile (“C. diff”) infection is a leading cause of hospital-associated diarrhea, and the frequency and severity of infections are on the rise. D. Borden Lacy, Ph.D., associate professor of Pathology, Microbiology and Immunology, and colleagues recently demonstrated that the C. difficile toxin, TcdB, induces rapid cell death of human colon cell lines and pig colonic...

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Cell changes en route to stomach cancer

Sep. 26, 2013—Molecular characterization of pre-cancerous changes in cells lining the stomach could point to lesions with a greater risk of progression to cancer.

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Dual-action enzyme protects esophagus

May. 9, 2013—An antioxidant enzyme also functions as a tumor suppressor to limit cancer development in the esophagus.

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Bird’s eye view of gut development

Nov. 19, 2012—A new map of the developing gut of quail offers valuable tool for studying intestinal diseases.

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Enzyme counters stomach acid attack

Sep. 11, 2012—Dysfunction or loss of an “antioxidant” enzyme may lead to higher risk for esophageal cancer in patients with gastric reflux disease.

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Intestinal artillery launches anti-bacterial attack

May. 14, 2012—The epithelial cells that line the intestines have a newly discovered mechanism for protecting us against microbes: they fire anti-bacterial "bullets" into the gut.

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