GWAS Archives
Study shows how a protein coding gene confers breast cancer susceptibility during DNA transcription
Sep. 30, 2021—Vanderbilt-Ingram Cancer Center research is providing new insights into how genetic variants convey breast cancer susceptibility by altering the transcription factor proteins that convert DNA strands into RNA.
Drug allergy labels in medical records power searches for gene-drug associations
Jun. 17, 2021— by Paul Govern A meta-analysis published in 1998 in the Journal of the American Medical Association estimated that, leaving aside overdoses and cases of drug abuse, 2.2 million patients admitted to U.S. hospitals in 1994 (6.7% of the total) were either admitted due to a serious adverse drug reaction or had a serious ADR...
New tool to probe genetic mechanisms of disease
Oct. 22, 2020—Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.
Genes spell penicillin allergy risk
Oct. 1, 2020—Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction.
Potential prostate cancer biomarkers
Sep. 19, 2019—An analysis of more than 140,000 people of European ancestry has identified blood protein biomarkers associated with prostate cancer risk.
Cancer susceptibility genes
Aug. 26, 2019—Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.
Study identifies novel genetic factors for colorectal cancer risk
Jan. 10, 2019—A large-scale study conducted among East Asians and led by Vanderbilt researchers has identified multiple, previously unknown genetic risk factors for colorectal cancer.
Probing the genetics of fibroids
Oct. 1, 2018—A new study identified multiple genetic locations associated with the size and number of uterine fibroids — common non-cancerous uterine tumors.
Connecting an asthma gene to leukemia
Aug. 2, 2018—A receptor previously implicated in asthma may also play roles in other allergic diseases and in leukemia, Vanderbilt researchers have discovered.
Vanderbilt study links gene expression, disease association data
Jul. 26, 2018—An international team of researchers has integrated gene expression and disease association data to better understand the biological mechanisms of complex human diseases.
Shared genetics may shape treatment options for certain brain disorders
Jun. 14, 2018—Symptoms of schizophrenia and bipolar disorder, including psychosis, depression and manic behavior, have both shared and distinguishing genetic factors, an international consortium led by researchers from Vanderbilt University and Virginia Commonwealth University is reporting.
Probing the genetics of autoimmunity
Jul. 21, 2017—Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets.
