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GWAS Archives

A biomarker for early Type 2 diabetes

Feb. 1, 2024—Genetic analyses suggest that branched chain amino acids may be a sensitive biomarker of early or subclinical Type 2 diabetes and could be used to identify risk and implement preventive measures.

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New reference tool supports replication of DNA biobank studies

Aug. 31, 2023—Vanderbilt researchers created a phenotype-genotype reference map to assess data quality in DNA biobanks.

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Breast cancer genetics: new insights

Feb. 16, 2023—Largest genetic study of breast cancer to date identifies 222 genetic risk loci, 137 genes and multiple signaling pathways associated with risk, providing important new insights.

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Study examines genetic risk for suicide attempt

Nov. 30, 2021—New research from Vanderbilt identifies the first replicated genomic region contributing to risk of suicide attempt and confirms that genetic risk for the trait is not driven solely by risk for psychiatric disorders.

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Study shows how a protein coding gene confers breast cancer susceptibility during DNA transcription

Sep. 30, 2021—Vanderbilt-Ingram Cancer Center research is providing new insights into how genetic variants convey breast cancer susceptibility by altering the transcription factor proteins that convert DNA strands into RNA.

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Drug allergy labels in medical records power searches for gene-drug associations

Jun. 17, 2021—  by Paul Govern A meta-analysis published in 1998 in the Journal of the American Medical Association estimated that, leaving aside overdoses and cases of drug abuse, 2.2 million patients admitted to U.S. hospitals in 1994 (6.7% of the total) were either admitted due to a serious adverse drug reaction or had a serious ADR...

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New tool to probe genetic mechanisms of disease

Oct. 22, 2020—Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases.

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Genes spell penicillin allergy risk

Oct. 1, 2020—Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction.

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Potential prostate cancer biomarkers

Sep. 19, 2019—An analysis of more than 140,000 people of European ancestry has identified blood protein biomarkers associated with prostate cancer risk.

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Cancer susceptibility genes

Aug. 26, 2019—Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations.

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Study identifies novel genetic factors for colorectal cancer risk

Jan. 10, 2019—A large-scale study conducted among East Asians and led by Vanderbilt researchers has identified multiple, previously unknown genetic risk factors for colorectal cancer.

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Probing the genetics of fibroids

Oct. 1, 2018—A new study identified multiple genetic locations associated with the size and number of uterine fibroids — common non-cancerous uterine tumors.

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