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h. pylori Archives

Nasty microbe H. pylori has Achilles’ heel

Nov. 16, 2023—Vanderbilt researchers found that an H. pylori enzyme is essential for colonization of the stomach, suggesting it as a promising therapeutic target for H. pylori infection.

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H. pylori and lung cancer

Aug. 1, 2022—Specific biomarkers for H. pylori — a bacterium that infects the stomach — were associated with increased risk of lung cancer, Vanderbilt researchers have discovered.

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H. pylori, lipid loss and stomach cancer

Jan. 17, 2022—H. pylori infection — a strong risk factor for stomach cancer — changes the composition of stomach lipids, which could offer new biomarkers for detecting premalignant changes, Vanderbilt researchers discovered.

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Study finds genetic factor undermines H. pylori treatment

Aug. 4, 2021—Helicobacter pylori, a stomach-dwelling bacterium, is a strong risk factor for gastric cancer, peptic ulcers and other debilitating gastrointestinal disorders. Yet efforts to eradicate it using a combination of antibiotics and proton pump inhibitors (PPIs), which suppress gastric acid production, often fail.

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Factor involved in stomach injury response identified

Oct. 15, 2020—Researchers at Vanderbilt University Medical Center have identified a key factor that coordinates the body’s repair response to severe injury in the stomach caused, most commonly, by infection by the bacterium Helicobacter pylori.

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Stomach bug hit-and-run

Jul. 23, 2020—The H. pylori machinery that “injects” an oncoprotein into stomach cells contributes to the development of gastric cancer, Vanderbilt researchers demonstrate.

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Powering H. pylori pathogenesis

Feb. 6, 2020—Timothy Cover and colleagues report new insights into the sources of energy used by a bacterial “machine” linked to the pathogenesis of stomach cancer.

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A step toward gastric cancer

Oct. 3, 2019—New research findings provide insight into the detrimental events that develop in response to H. pylori infection.

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Receptor’s role in stopping H. pylori

Apr. 25, 2019—The immune receptor NOD1 may be a prime target for preventing or treating H. pylori infections — the most significant risk factor for stomach cancer, Vanderbilt researchers have discovered.

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Cancer prevention drug also disables H. pylori bacterium

Mar. 28, 2019—A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer, Vanderbilt researchers have discovered.

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Probing H. pylori cancer protein

Feb. 14, 2019—Understanding how a bacterial protein that influences the risk of stomach cancer is produced could guide new strategies for treatment.

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Toxin floats on lipid rafts

Apr. 23, 2018—The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells.

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